Towne A R, Waterhouse E J, Boggs J G, Garnett L K, Brown A J, Smith J R, DeLorenzo R J
Department of Neurology, Medical College of Virginia of Virginia Commonwealth University, Richmond 23298-0599, USA.
Neurology. 2000 Jan 25;54(2):340-5. doi: 10.1212/wnl.54.2.340.
Nonconvulsive status epilepticus (NCSE) is a form of status epilepticus (SE) that is an often unrecognized cause of coma.
To evaluate the presence of NCSE in comatose patients with no clinical signs of seizure activity.
A total of 236 patients with coma and no overt clinical seizure activity were monitored with EEG as part of their coma evaluation. This study was conducted during our prospective evaluation of SE, where it has been validated that we identify over 95% of all SE cases at the Medical College of Virginia Hospitals. Only cases that were found to have no clinical signs of SE were included in this study.
EEG demonstrated that 8% of these patients met the criteria for the diagnosis of NCSE. The study included an age range from 1 month to 87 years.
This large-scale EEG evaluation of comatose patients without clinical signs of seizure activity found that NCSE is an underrecognized cause of coma, occurring in 8% of all comatose patients without signs of seizure activity. EEG should be included in the routine evaluation of comatose patients even if clinical seizure activity is not apparent.
非惊厥性癫痫持续状态（NCSE）是癫痫持续状态（SE）的一种形式，常常是昏迷未被识别的原因。
评估无癫痫发作临床体征的昏迷患者中NCSE的存在情况。
作为昏迷评估的一部分，对总共236例无明显临床癫痫发作活动的昏迷患者进行脑电图（EEG）监测。本研究在我们对SE的前瞻性评估期间进行，在弗吉尼亚医学院医院已验证我们能识别超过95%的所有SE病例。本研究仅纳入未发现有SE临床体征的病例。
EEG显示这些患者中有8%符合NCSE的诊断标准。研究纳入的年龄范围为1个月至87岁。
对无癫痫发作临床体征的昏迷患者进行的这项大规模EEG评估发现，NCSE是昏迷未被充分认识的原因，在所有无癫痫发作体征的昏迷患者中占8%。即使没有明显的临床癫痫发作活动，EEG也应纳入昏迷患者的常规评估中。
