O'Regan S, Kaplan B S, Chesney R W, Ayoub J I, Drummond K N
Am J Dis Child. 1976 Sep;130(9):937-40. doi: 10.1001/archpedi.1976.02120100027004.
Eight children with acute leukemia in relapse were hypokalemic during their hospital course. All had accompanying hypophosphatemia, and three had mild metabolic alkalosis. Potassium chloride supplementation in each case resulted in resolution of the electrolyte and acid-base disturbances. These findings were not present in patients with conditions newly diagnosed or those in remission. The pathogenesis of the electrolyte and acidbase disturbances was not evident and was not related to antibiotic or cytotoxic drug therapy, but may have been related to the patients' poor nutritional status. Seven of the eight patients died within six months of the hypokalemic episode. Hypokalemia may be a common accompaniment of terminal leukemia.
8例急性白血病复发患儿在住院期间出现低钾血症。所有患儿均伴有低磷血症，3例有轻度代谢性碱中毒。每例补充氯化钾后，电解质和酸碱紊乱均得到缓解。新诊断患者或缓解期患者未出现这些情况。电解质和酸碱紊乱的发病机制尚不明确，与抗生素或细胞毒性药物治疗无关，但可能与患者营养状况差有关。8例患者中有7例在低钾血症发作后6个月内死亡。低钾血症可能是终末期白血病的常见伴随症状。
