Osman L M, Calder C, Robertson R, Friend J A, Legge J S, Douglas J G
Department of Medicine and Therapeutics, Aberdeen University and Thoracic Medicine Unit, Aberdeen Royal Hospitals Trust, Aberdeen, Scotland.
Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 1):498-503. doi: 10.1164/ajrccm.161.2.9904063.
This report assesses Quality of Life (QoL) and its relationship to current symptoms and prospective medical contact among 396 adult patients with asthma. Patients were 16 to 52 yr of age and in the care of family physicians in the northeast of Scotland. All patients had been prescribed asthma medication within the previous 3 mo. Mean %pred FEV(1) was 87.4, mean %pred PEF was 85.1; 41% reported respiratory symptoms every week in the month before interview. Patients completed the SF-36, SF-12, and St. George's Respiratory Questionnaire (SGRQ) scales. Although mean scores on the SF-36 and SF-12 were close to population norms for patients without chronic illness, the presence of any respiratory symptoms in the month before interview was related to significantly lower QoL scores on the SF-36 scales of Physical Functioning, Energy, Mental Health, Pain, and Health Perception: the SF-12 Physical Functioning scale, and the SGRQ Symptoms, Impact and Activities scales. Physician contact for asthma in the 12 mo after interview was significantly related to SF-36, SF-12, and SGRQ scores at time of interview; however, when adjusted for symptoms at time of interview, only the SGRQ scales remained significant predictors of prospective physician contact. We conclude that respiratory symptoms have significant impact on QoL among patients with mild asthma, measured by generic and respiratory QoL scales, but that a specific respiratory scale is better able to discriminate patients who will seek physician care for asthma.
本报告评估了396例成年哮喘患者的生活质量（QoL）及其与当前症状和未来就医情况的关系。患者年龄在16至52岁之间，由苏格兰东北部的家庭医生负责诊治。所有患者在过去3个月内均已开具哮喘药物处方。平均预计第一秒用力呼气容积（%pred FEV(1)）为87.4，平均预计呼气峰流速（%pred PEF）为85.1；41%的患者在访谈前一个月每周都有呼吸道症状。患者完成了SF - 36、SF - 12和圣乔治呼吸问卷（SGRQ）量表。尽管SF - 36和SF - 12的平均得分接近无慢性病患者的总体标准，但访谈前一个月出现任何呼吸道症状与SF - 36身体功能、精力、心理健康、疼痛和健康感知量表、SF - 12身体功能量表以及SGRQ症状、影响和活动量表上显著更低的生活质量得分相关。访谈后12个月内因哮喘就医与访谈时的SF - 36、SF - 12和SGRQ得分显著相关；然而，在调整访谈时的症状后，只有SGRQ量表仍然是未来就医的显著预测指标。我们得出结论，呼吸道症状对轻度哮喘患者的生活质量有显著影响，通过通用和呼吸道生活质量量表来衡量，但特定的呼吸道量表更能区分哪些患者会因哮喘寻求医生治疗。
