Ramon R, Sawadogo D, Koko F S, Noba V, Likikouët R, Gourvellec G, Viho I, Mandelbrot L, Dabis F, Ekra C W, Msellati P
Laboratoire d'Hématologie, Centre Hospitalier Universitaire (CHU) de Yopougon, Abidjan, France.
Trans R Soc Trop Med Hyg. 1999 Jul-Aug;93(4):419-22. doi: 10.1016/s0035-9203(99)90143-8.
To describe the haematological profile of pregnant women and to compare these characteristics according to HIV serostatus in Abidjan, Côte d'Ivoire, a cross-sectional study was made in the context of a research intervention programme to reduce mother-to-child transmission (MTCT) of HIV (ANRS 049 trial). HIV testing was systematically proposed to pregnant women attending the mother and child health clinic of a community health centre. Blood samples were tested for HIV antibodies using Genelavia and Peptilav. The haematological parameters were measured with a Coulter counter. From May 1995 to March 1996, 1646 pregnant women accepted HIV testing and had a full blood count available. The prevalence of HIV infection was 12.0% (n = 197). The prevalence of anaemia (haemoglobin [Hb] < 11 g/dL) was 70.1%, n = 1155 (95% confidence interval 68-72%) and significantly higher in HIV+ (81.7%, n = 161) than in HIV- women (68.9%, n = 994) (P < 0.001). Severe anaemia (Hb < 7 g/dL) was present in 1.9% of the women (n = 31), 4.6% (n = 9) in HIV+ and 1.5% (n = 22) in HIV- women (P < 0.001). HIV infection, primigravidae and secundigravidae were factors independently associated with anaemia. Anaemia was highly prevalent in this population while severe anaemia was rare. HIV infection was a contributor to anaemia in pregnancy. As zidovudine, with its known haematological toxicity, has recently been introduced to prevent MTCT of HIV in developing countries, screening HIV+ women for severe anaemia is necessary.
为描述科特迪瓦阿比让孕妇的血液学特征，并根据艾滋病毒血清学状态比较这些特征，在一项旨在减少艾滋病毒母婴传播（MTCT）的研究干预项目（ANRS 049试验）背景下开展了一项横断面研究。系统地向在社区卫生中心母婴保健诊所就诊的孕妇提供艾滋病毒检测。使用Genelavia和Peptilav对血样进行艾滋病毒抗体检测。用库尔特计数器测量血液学参数。1995年5月至1996年3月，1646名孕妇接受了艾滋病毒检测并进行了全血细胞计数。艾滋病毒感染率为12.0%（n = 197）。贫血（血红蛋白[Hb]<11 g/dL）患病率为70.1%，n = 1155（95%置信区间68 - 72%），艾滋病毒阳性者（81.7%，n = 161）的贫血患病率显著高于艾滋病毒阴性者（68.9%，n = 994）（P<0.001）。严重贫血（Hb<7 g/dL）的女性占1.9%（n = 31），艾滋病毒阳性者中为4.6%（n = 9），艾滋病毒阴性者中为1.5%（n = 22）（P<0.001）。艾滋病毒感染、初产妇和经产妇是与贫血独立相关的因素。贫血在该人群中非常普遍，而严重贫血很少见。艾滋病毒感染是孕期贫血的一个因素。由于齐多夫定具有已知的血液学毒性，最近已被引入发展中国家以预防艾滋病毒母婴传播，因此有必要对艾滋病毒阳性女性进行严重贫血筛查。
