Jones L M, Spector S L, English G M, Taylor-Dawson K
Ann Allergy. 1979 Mar;42(3):139-44.
Flunisolide nasal spray was compared to its propylene and polyethylene glycol vehicle in a randomized double-blind study of 20 adult patients with perennial rhinitis. After a two-week baseline period patients received either active flunisolide 50 microgram q.i.d. or placebo for four weeks. Laboratory studies included serum 8 a.m. cortisols, nasal air-flow measurements and nasal smears for eosinophils and fungi. Patients kept daily symptom diaries. There was no difference between active and placebo groups for sneezing, runny nose or nose blowing. Although post-nasal drip showed the greatest improvement in the active group, there was a trend for improvement in both groups. By the second week the percentage of eosinophils on nasal smear significantly decreased in both groups. Nasal air-flow measurements also showed improvement in both active and placebo groups. There was no change in serum cortisol levels compared to baseline. Side effects were similar in both active and placebo groups. Although no positive fungal cultures were obtained during the double-blind study. Candida was cultured during the long-term program in one patient.
在一项针对20名常年性鼻炎成年患者的随机双盲研究中，对氟尼缩松鼻喷雾剂与其丙二醇和聚乙二醇赋形剂进行了比较。在为期两周的基线期后，患者接受4周的活性氟尼缩松（每日4次，每次50微克）或安慰剂治疗。实验室研究包括上午8点的血清皮质醇、鼻气流测量以及鼻涂片检查嗜酸性粒细胞和真菌。患者记录每日症状日记。在打喷嚏、流鼻涕或擤鼻涕方面，活性组和安慰剂组之间没有差异。尽管后鼻滴漏在活性组中改善最为明显，但两组均有改善趋势。到第二周时，两组鼻涂片上嗜酸性粒细胞的百分比均显著下降。鼻气流测量结果显示活性组和安慰剂组均有改善。与基线相比，血清皮质醇水平没有变化。活性组和安慰剂组的副作用相似。虽然在双盲研究期间未获得阳性真菌培养结果，但在长期治疗项目中有1名患者培养出念珠菌。
