Straubhaar M, Orgül S, Gugleta K, Schötzau A, Erb C, Flammer J
University Eye Clinic Basel, Switzerland.
Arch Ophthalmol. 2000 Feb;118(2):211-5. doi: 10.1001/archopht.118.2.211.
To evaluate normal choroidal blood flow and its relationship with various factors such as age, systemic blood pressure, and intraocular pressure (IOP).
A total of 70 healthy subjects were recruited. Choroidal blood flow was assessed using a method based on laser Doppler flowmetry (LDF) technique. The LDF parameters of velocity, volume, and flux were obtained. The influence of age, mean systemic blood pressure, IOP, smoking, and sex on choroidal hemodynamic parameters was assessed in a multiple linear regression model. The correlations between interocular difference in IOP and interocular differences in the LDF parameters were assessed by means of the Pearson linear correlation factor.
Velocity decreased significantly (P = .03) with advancing age of the subjects and volume increased significantly (P = .02) with increasing IOP. Mean blood pressure, smoking, and sex had no influence on the choroidal LDF parameters. Interocular difference in IOP correlated significantly with interocular difference in volume (R = 0.34, P<.005).
Choroidal blood flow velocity decreased with increasing age of the subjects, while the volume of moving erythrocytes decreased with lower IOP.
评估正常脉络膜血流及其与年龄、全身血压和眼压（IOP）等各种因素的关系。
共招募70名健康受试者。使用基于激光多普勒血流仪（LDF）技术的方法评估脉络膜血流。获得LDF的速度、体积和通量参数。在多元线性回归模型中评估年龄、平均全身血压、IOP、吸烟和性别对脉络膜血流动力学参数的影响。通过Pearson线性相关系数评估眼压的眼间差异与LDF参数的眼间差异之间的相关性。
随着受试者年龄的增长，速度显著降低（P = .03），随着眼压升高，体积显著增加（P = .02）。平均血压、吸烟和性别对脉络膜LDF参数无影响。眼压的眼间差异与体积的眼间差异显著相关（R = 0.34，P<.005）。
脉络膜血流速度随着受试者年龄的增加而降低，而移动红细胞的体积随着眼压降低而减少。
