恰加斯病的寄生虫学治愈：是否可行？是否重要？ - Suppr

Parasitological cure of Chagas disease: is it possible? Is it relevant?

作者信息

Urbina J A

机构信息

Laboratorio de Química Biológica, Centro de Bioquímica y Biofísica, Instituto Venezolano de Invstigaciones Cientificas, Caracas, Venezuela.

出版信息

Mem Inst Oswaldo Cruz. 1999;94 Suppl 1:349-55. doi: 10.1590/s0074-02761999000700068.

DOI:10.1590/s0074-02761999000700068

PMID:10677754

Abstract

摘要

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Parasitological cure of Chagas disease: is it possible? Is it relevant?恰加斯病的寄生虫学治愈：是否可行？是否重要？

Mem Inst Oswaldo Cruz. 1999;94 Suppl 1:349-55. doi: 10.1590/s0074-02761999000700068.

Evaluation of nifurtimox treatment of chronic Chagas disease by means of several parasitological methods.采用多种寄生虫学方法评估硝呋替莫治疗慢性恰加斯病。

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Can a killer be arrested?凶手能被逮捕吗？

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Chemotherapy of Trypanosoma cruzi infections.克氏锥虫感染的化疗。

Adv Pharmacol Chemother. 1975;13:1-81. doi: 10.1016/s1054-3589(08)60229-x.

The urgent need to develop new drugs and tools for the treatment of Chagas disease.开发治疗恰加斯病的新药和工具的迫切需求。

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Cure of short- and long-term experimental Chagas' disease using D0870.使用D0870治愈短期和长期实验性恰加斯病。

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Low-dose of benznidazole promotes therapeutic cure in experimental chronic Chagas' disease with absence of parasitism in blood, heart and colon.低剂量苯硝唑促进实验性慢性恰加斯病的治疗性治愈，血液、心脏和结肠中无寄生虫。

Exp Parasitol. 2020 Mar;210:107834. doi: 10.1016/j.exppara.2020.107834. Epub 2020 Jan 21.

Course of Chronic Trypanosoma cruzi Infection after Treatment Based on Parasitological and Serological Tests: A Systematic Review of Follow-Up Studies.基于寄生虫学和血清学检测的治疗后慢性克氏锥虫感染病程：随访研究的系统评价

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Combined use of ascorbic acid and cyanocobalamin in clearance of Trypanosoma cruzi.抗坏血酸与氰钴胺联合使用对克氏锥虫的清除作用

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Recent clinical trials for the etiological treatment of chronic chagas disease: advances, challenges and perspectives.慢性恰加斯病病因治疗的近期临床试验：进展、挑战与展望

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Solid Nanomedicines of Nifurtimox and Benznidazole for the Oral Treatment of Chagas Disease.用于口服治疗恰加斯病的硝呋替莫和苯硝唑固体纳米药物。

Pharmaceutics. 2022 Aug 29;14(9):1822. doi: 10.3390/pharmaceutics14091822.

Trypanocidal drugs for late-stage, symptomatic Chagas disease (Trypanosoma cruzi infection).用于晚期有症状的恰加斯病（克氏锥虫感染）的杀锥虫药物。

Cochrane Database Syst Rev. 2020 Dec 11;12(12):CD004102. doi: 10.1002/14651858.CD004102.pub3.

Dibenzylideneacetones Are Potent Trypanocidal Compounds That Affect the Trypanosoma cruzi Redox System.二苄叉丙酮是强效杀锥虫化合物，可影响克氏锥虫的氧化还原系统。

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Design, synthesis and biological evaluation of WC-9 analogs as antiparasitic agents.设计、合成及抗寄生虫药物 WC-9 类似物的生物评价。

Eur J Med Chem. 2013 Nov;69:480-9. doi: 10.1016/j.ejmech.2013.09.009. Epub 2013 Sep 18.

Design or screening of drugs for the treatment of Chagas disease: what shows the most promise?治疗恰加斯病的药物的设计或筛选：有哪些最有前途的方法？

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Antitrypanosomal activity of Senna villosa in infected BALB/c mice with Trypanosoma cruzi during the sub acute phase of infection.绒毛番泻叶对克氏锥虫感染的BALB/c小鼠在感染亚急性期的抗锥虫活性。

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Synthesis and biological evaluation of new 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase.新型 2-烷氨基乙基-1,1-双膦酸的合成与生物评价，针对法呢基二磷酸合酶的克氏锥虫和刚地弓形虫。

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Nitric oxide donor trans-[RuCl([15]aneN)NO] as a possible therapeutic approach for Chagas' disease.氮氧供体顺式-[RuCl([15]aneN)NO] 可能成为治疗恰加斯病的一种方法。

Br J Pharmacol. 2010 May;160(2):270-82. doi: 10.1111/j.1476-5381.2009.00576.x. Epub 2010 Jan 27.

Two approaches to discovering and developing new drugs for Chagas disease.两种发现和开发治疗恰加斯病新药的方法。

Mem Inst Oswaldo Cruz. 2009 Jul;104 Suppl 1(0 1):263-9. doi: 10.1590/s0074-02762009000900034.

Prodrugs for the treatment of neglected diseases.用于治疗被忽视疾病的前体药物。

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Parasitological cure of Chagas disease: is it possible? Is it relevant?

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