Jiang Y, He A, Xia S
Zhonghua Jie He He Hu Xi Za Zhi. 1995 Aug;18(4):209-11, 254.
It was proposed that nm23 gene may function as a suppressor gene for tumor metastasis. Using an antibody to NDPK, levels of NDPK/nm23 expression in lung carcinomas were examined immunohistochemically, 45 of 58 squamous carcinomas and 26 of 36 adenocarcinomas showed strong immunoreactivity for NDPK/nm23 in most of cancer cells within tumor tissues. On some normal bronchial epithelium and serous glands, there also show weak expression. No relationship was found between NDPK/nm23 expression and clinicopathological parameters including tumor grade, size, nodal involvement and stage but the increases in NDPK/nm23 expression were stronger in advanced stages of squamous cell carcinomas. In conclusion, our results indicate that the increased NDPK/nm23 expression in the analysed carcinomas is not consistent with the proposed metastasis-suppressor function, but the nm23 gene may be implicated in the mechanism of carcinogenic process and tumor progression.
有人提出nm23基因可能作为肿瘤转移的抑制基因发挥作用。使用抗NDPK抗体，通过免疫组织化学方法检测肺癌中NDPK/nm23的表达水平，58例鳞状细胞癌中的45例和36例腺癌中的26例在肿瘤组织内的大多数癌细胞中显示出对NDPK/nm23的强免疫反应性。在一些正常支气管上皮和浆液腺中也显示出弱表达。未发现NDPK/nm23表达与包括肿瘤分级、大小、淋巴结受累和分期在内的临床病理参数之间存在关联，但在鳞状细胞癌晚期，NDPK/nm23表达的增加更为明显。总之，我们的结果表明，在所分析的癌中NDPK/nm23表达的增加与所提出的转移抑制功能不一致，但nm23基因可能与致癌过程和肿瘤进展机制有关。
