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Ro 31-8220 inhibits release of interleukin-1 and interleukin-6 from mouse peritoneal macrophages induced by fibrin fibrinogen degradation products.

作者信息

Zhou B, Zhang J P, Hu Z L, Tan Y X, Qian D H

机构信息

Department of Pharmacology, College of Pharmacy, Second Military Medical University, Shanghai, China.

出版信息

Zhongguo Yao Li Xue Bao. 1999 May;20(5):449-51.

PMID:10678095
Abstract

AIM

To study the effect of fibrin fibrinogen degradation products (FFDP) on release of interleukin-1 (IL-1) and interleukin-6 (IL-6) from mouse peritoneal macrophages, and the effect of a new selectively potent protein kinase C inhibitor Ro 31-8220 (Ro).

METHODS

IL-1 and IL-6 activities were measured by thymocyte proliferation assay and B9 cell proliferation methyl thiazolyl tetrazolium (MTT) colorimetric method, respectively.

RESULTS

Ro 0.01-1 mumol.L-1 obviously inhibited FFDP-induced release of IL-1 and IL-6 from mouse peritoneal macrophages.

CONCLUSION

Ro exerted inhibitory effects on FFDP-induced release of IL-1 and IL-6 in vitro.

摘要

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