Kosaka H, Omata N, Omori M, Shimoyama T, Murata T, Kashikura K, Takahashi T, Murayama J, Yonekura Y, Wada Y
Department of Neuropsychiatry, University of Fukui Matsuoka, Fukui 910-1193, Japan.
J Neurol Neurosurg Psychiatry. 2006 Dec;77(12):1376-80. doi: 10.1136/jnnp.2005.073288.
To explore the aetiology of pathological laughing, a 65-year-old woman with pathological laughing was examined by 3-T functional magnetic resonance imaging (fMRI) before and after treatment with drugs. Here, we report that the patient consistently showed exaggerated pontine activation during the performance of three tasks before treatment, whereas abnormal pontine activation was no longer found after successful treatment with the selective serotonin reuptake inhibitor, paroxetine. Our findings in this first fMRI study of pathological laughing suggest that serotonergic replacement decreases the aberrant activity in a circuit that involves the pons.
为探究病理性发笑的病因，一名患有病理性发笑的65岁女性在药物治疗前后接受了3T功能磁共振成像（fMRI）检查。在此，我们报告该患者在治疗前执行三项任务期间脑桥激活持续增强，而在用选择性5-羟色胺再摄取抑制剂帕罗西汀成功治疗后，异常脑桥激活消失。我们在这项关于病理性发笑的首次fMRI研究中的发现表明，5-羟色胺能补充减少了涉及脑桥的回路中的异常活动。
