Bruno R L
The Post-Polio Institute, Englewood Hospital and Medical Center, New Jersey, USA.
Am J Phys Med Rehabil. 2000 Jan-Feb;79(1):4-12. doi: 10.1097/00002060-200001000-00003.
Nonparalytic polio (NPP) is commonly thought to be synonymous with "abortive polio," in which the poliovirus neither entered the central nervous system nor damaged neurons. Described are two epidemic illness-"The Summer Grippe" and Iceland disease-apparently caused by a low virulence but neuropathic type 2 poliovirus. Studies show that neuronal lesions in the brain and spinal cord and muscle weakness were common in NPP, and epidemiologic studies document late-onset weakness and fatigue in 14% to 42% of NPP survivors. These findings indicate that clinicians should not require a history of paralytic polio, electromyographic evidence of denervation, and new muscle weakness for the diagnosis of "Postpolio Syndrome" but should be aware that NPP, and possibly even poliovirus-induced "minor illnesses," can be associated with acute central nervous system damage and late-onset muscle weakness and fatigue.
非麻痹性脊髓灰质炎（NPP）通常被认为与“顿挫型脊髓灰质炎”同义，即脊髓灰质炎病毒既未进入中枢神经系统，也未损伤神经元。文中描述了两种流行性疾病——“夏季流感”和冰岛病，显然是由低毒力但具有神经病变性的2型脊髓灰质炎病毒引起的。研究表明，在NPP中，脑和脊髓的神经元损伤以及肌肉无力很常见，流行病学研究记录了14%至42%的NPP幸存者出现迟发性无力和疲劳。这些发现表明，临床医生在诊断“小儿麻痹后遗症”时，不应要求有麻痹性脊髓灰质炎病史、去神经支配的肌电图证据和新出现的肌肉无力，而应意识到NPP，甚至可能是脊髓灰质炎病毒引起的“轻症疾病”，都可能与急性中枢神经系统损伤以及迟发性肌肉无力和疲劳有关。
