Esteban Jesús
Unidad de Esclerosis lateral amiotrófica, Sección Neuromuscular, Servicio de Neurología, Hospital Universitario 12 de Octubre, Madrid, España.
Rev Esp Salud Publica. 2013 Sep-Oct;87(5):517-22. doi: 10.4321/S1135-57272013000500010.
In 1875 M. Raymond described a progressive muscle wasting and weakness in 3 individuals survivors of childhood acute poliomyelitis. Jean-Martin Charcot suggested that the initial injury should let these guys neurons more sensitive to develop posterior spinal diseases and new weakness was the result of overuse of the affected muscles. In 1979, after the publication of the description given by a 57 year old patient on motor difficulties that developed after suffering of polio in childhood, there was a very significant increase of comments of other individuals with similar symptoms, reaching wedged in the 80s the term of post-polio syndrome. The term is reserved for describing the development of new neurological symptoms, especially for the development of muscle weakness, muscle atrophy and new muscle fatigue not explained by other medical causes, and appear after more than 15 years of infection acute. Is estimated to affect 20 to 85% of individuals with a history of polio in childhood. In 2000 first described the diagnostic criteria. This syndrome determines a change in the functional abilities. Its pathogenesis is unknown, may be associated with aging. It could also be due to an inflammatory persistent or be influenced by genetic factors. There is no effective drug treatment, so I can only recommend symptomatic and moderate muscle training.
1875年，雷蒙德先生描述了3名儿童急性脊髓灰质炎幸存者出现进行性肌肉萎缩和无力的情况。让-马丁·沙尔科认为，最初的损伤会使这些人的神经元对发生脊髓后部疾病更加敏感，而新出现的无力是受累肌肉过度使用的结果。1979年，在一名57岁患者描述了童年患脊髓灰质炎后出现的运动困难后，有类似症状的其他患者的病例报告显著增加，到了80年代，“小儿麻痹后遗症”这一术语被广泛使用。该术语用于描述新的神经症状的出现，尤其是肌肉无力、肌肉萎缩和新出现的肌肉疲劳，这些症状无法用其他医学原因解释，且在急性感染15年以上后出现。据估计，童年有脊髓灰质炎病史的人中，20%至85%会受到影响。2000年首次描述了诊断标准。这种综合征会导致功能能力的改变。其发病机制尚不清楚，可能与衰老有关。也可能是由于持续性炎症或受遗传因素影响。目前没有有效的药物治疗方法，因此只能建议进行对症治疗和适度的肌肉训练。
