Rogers S L, Gelfand V I
Department of Pharmacology, University of California at San Francisco, San Francisco, CA 94143-0450, USA.
Curr Opin Cell Biol. 2000 Feb;12(1):57-62. doi: 10.1016/s0955-0674(99)00057-5.
Cytoskeleton-associated motor proteins typically drive organelle movements in eukaryotic cells in a manner that is tightly regulated, both spatially and temporally. In the past year, a novel organelle transport mechanism utilizing actin polymerization was described. Important advances were also made in the assignment of functions to several new motors and in our understanding of how motor proteins are regulated during organelle transport. In addition, insights were gained into how and why organelles are transported cooperatively along the microtubule and actin cytoskeletons, and into the importance of motor-mediated transport in the organization of the cytoskeleton itself.
细胞骨架相关的运动蛋白通常以在空间和时间上受到严格调控的方式驱动真核细胞中的细胞器运动。在过去的一年里，描述了一种利用肌动蛋白聚合的新型细胞器运输机制。在赋予几种新的运动蛋白功能以及我们对细胞器运输过程中运动蛋白如何被调控的理解方面也取得了重要进展。此外，对于细胞器如何以及为何沿着微管和肌动蛋白细胞骨架协同运输，以及运动介导的运输在细胞骨架自身组织中的重要性也有了深入了解。
