Department of Anatomy, University of California, San Francisco, CA 94158-2517, USA.
Cold Spring Harb Perspect Biol. 2013 Feb 1;5(2):a013789. doi: 10.1101/cshperspect.a013789.
Cell polarity is fundamental for the architecture and function of epithelial tissues. Epithelial polarization requires the intervention of several fundamental cell processes, whose integration in space and time is only starting to be elucidated. To understand what governs the building of epithelial tissues during development, it is essential to consider the polarization process in the context of the whole tissue. To this end, the development of three-dimensional organotypic cell culture models has brought new insights into the mechanisms underlying the establishment and maintenance of higher-order epithelial tissue architecture, and in the dynamic remodeling of cell polarity that often occurs during development of epithelial organs. Here we discuss some important aspects of mammalian epithelial morphogenesis, from the establishment of cell polarity to epithelial tissue generation.
细胞极性对于上皮组织的结构和功能至关重要。上皮极化需要几种基本细胞过程的干预，其在空间和时间上的整合才刚刚开始被阐明。为了了解在发育过程中是什么控制着上皮组织的构建，必须从整个组织的角度来考虑极化过程。为此，三维器官型细胞培养模型的发展为上皮组织建立和维持高级组织架构的机制以及在发育过程中上皮组织动态重塑中细胞极性的动态重塑提供了新的见解。在这里，我们讨论了哺乳动物上皮形态发生的一些重要方面，从细胞极性的建立到上皮组织的产生。
