VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent, 9052, Belgium; Department of Internal Medicine and Pediatrics, Ghent University, Ghent 9000, Belgium.
VIB-UGent Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent, 9052, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Mol Immunol. 2020 May;121:38-46. doi: 10.1016/j.molimm.2020.02.021. Epub 2020 Mar 6.
Dendritic cells function in the immune system to instruct adaptive immune cells to respond accordingly to different threats. While conventional dendritic cells can be subdivided into two main subtypes, termed cDC1s and cDC2s, it is clear that further heterogeneity exists within these subtypes, particularly for cDC2s. Understanding the signals involved in specifying each of these lineages and subtypes thereof is crucial to (i) enable us to determine their specific functions and (ii) put us in a position to be able to target these cells to promote or prevent a specific function in any given disease setting. Although we still have much to learn regarding the specification of these cells, here we review the most recent advances in our understanding of this and highlight some of the next questions for the future.
树突状细胞在免疫系统中发挥作用，指导适应性免疫细胞对不同的威胁做出相应的反应。虽然传统的树突状细胞可以细分为两种主要亚型，称为 cDC1 和 cDC2，但很明显，这些亚型内还存在进一步的异质性，尤其是 cDC2。了解参与指定这些谱系及其亚型的信号对于（i）使我们能够确定它们的特定功能，以及（ii）使我们能够靶向这些细胞以在任何特定疾病环境中促进或预防特定功能至关重要。尽管我们在这些细胞的特异性方面还有很多需要了解，但在这里我们回顾了我们在这方面理解的最新进展，并强调了未来的一些问题。
