Castro V, Rüngeler P, Murillo R, Hernandez E, Mora G, Pahl H L, Merfort I
Universidad de Costa Rica, Escuela de Química, San José, Costa Rica.
Phytochemistry. 2000 Jan;53(2):257-63. doi: 10.1016/s0031-9422(99)00510-5.
In Central America aerial parts of the Asteraceae Milleria quinqueflora are used in traditional medicine as a remedy for skin infections. Reinvestigation of this plant afforded thirteen sesquiterpene lactones (Sls), three of them are new. All isolated Sls were studied for their anti-inflammatory activity using the transcription factor NF-kappa B as molecular target. NF-kappa B is involved in the synthesis of inflammatory mediators, such as cytokines and chemokines. NF-kappa B DNA binding was inhibited at micromolar concentrations by all Sls.
在中美洲，菊科植物五花米勒草的地上部分在传统医学中被用作治疗皮肤感染的药物。对这种植物的重新研究得到了13种倍半萜内酯（Sls），其中3种是新的。以转录因子NF-κB为分子靶点，对所有分离得到的Sls的抗炎活性进行了研究。NF-κB参与炎症介质如细胞因子和趋化因子的合成。所有Sls在微摩尔浓度下均能抑制NF-κB与DNA的结合。
