Bendich A
New Product Research, SmithKline Beecham Consumer Healthcare, Parsippany, New Jersey 07054-3884, USA.
J Am Coll Nutr. 2000 Feb;19(1):3-12. doi: 10.1080/07315724.2000.10718907.
Many types of dietary supplements have been advocated for the reduction of certain symptoms of premenstrual syndrome (PMS). However, only one supplement-calcium-has been demonstrated to be of significant benefit in a large, rigorous, double-blind, placebo-controlled trial. Limited evidence suggests that magnesium, vitamin E and carbohydrate supplements might also be useful, but additional research is needed to confirm these findings. Trials of vitamin B6 supplementation have had conflicting results, and high doses of this vitamin taken for prolonged periods of time can cause neurological symptoms. Trials of evening primrose oil have also had conflicting results; the two most rigorous studies showed no evidence of benefit. A variety of herbal products are suggested to reduce symptoms of PMS. The efficacy of these products is uncertain because of a lack of consistent data from scientific studies. Health professionals should be aware of the possible use of these supplements and ask those with PMS about their use of such products and counsel them based upon the totality of evidence.
许多类型的膳食补充剂都被提倡用于减轻经前综合征（PMS）的某些症状。然而，在一项大型、严谨、双盲、安慰剂对照试验中，只有一种补充剂——钙——被证明有显著益处。有限的证据表明，镁、维生素E和碳水化合物补充剂可能也有用，但需要更多研究来证实这些发现。补充维生素B6的试验结果相互矛盾，长期服用高剂量这种维生素会导致神经症状。月见草油的试验结果也相互矛盾；两项最严谨的研究未显示出有益的证据。有人建议使用多种草药产品来减轻经前综合征的症状。由于缺乏科学研究的一致数据，这些产品的疗效尚不确定。健康专业人员应了解这些补充剂的可能用途，询问患有经前综合征的人是否使用此类产品，并根据全部证据为他们提供咨询。
