评估维生素D和维生素E补充剂对经前综合征的影响：一项随机、双盲、对照试验。
Evaluating the effects of vitamin D and vitamin E supplement on premenstrual syndrome: A randomized, double-blind, controlled trial.
作者信息
Dadkhah Hajar, Ebrahimi Elham, Fathizadeh Nahid
机构信息
Nursing and Midwifery Care Research Center, Faculty of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Reproductive Health, Student Research Committee, School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran.
出版信息
Iran J Nurs Midwifery Res. 2016 Mar-Apr;21(2):159-64. doi: 10.4103/1735-9066.178237.
BACKGROUND
Premenstrual syndrome (PMS) can cause problems in daily work and relationships.
MATERIALS AND METHODS
Eighty-six women were randomly assigned to two intervention groups and one control group. Patients were asked to fill out the PMS Daily Symptoms Record for 2 months, and then the participants were randomly assigned to one of the three study groups. Medical intervention was carried out for 2 months with the participants in each group receiving either a tablet containing 200 mg vitamin D, 100 mg vitamin E, or a placebo each day, respectively. After 2 months, the results of pre- and post-intervention were compared. P < 0.005 was considered significant.
RESULTS
After the intervention, the mean score of the syndrome significantly decreased in all the three groups (12, 16, and 8 participants had decreased scores in vitamin D, vitamin E, and placebo, respectively). The differences between groups were not significant (P > 0.05).
CONCLUSIONS
Supplemental therapy with vitamins D and E is an effective and affordable treatment for PMS.
背景
经前综合征（PMS）会给日常工作和人际关系带来问题。
材料与方法
86名女性被随机分为两个干预组和一个对照组。要求患者填写2个月的经前综合征每日症状记录，然后将参与者随机分配到三个研究组之一。每组参与者分别每天服用一片含200毫克维生素D、100毫克维生素E的片剂或安慰剂，进行2个月的医学干预。2个月后，比较干预前后的结果。P<0.005被认为具有显著性。
结果
干预后，三组综合征的平均得分均显著下降（维生素D组、维生素E组和安慰剂组分别有12名、16名和8名参与者得分下降）。组间差异不显著（P>0.05）。
结论
维生素D和E补充疗法是治疗经前综合征的一种有效且经济实惠的方法。
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