Mattusch F, Dufaux B, Heine O, Mertens I, Rost R
Laboratory Dr. Krone and Partner, Herford, Germany.
Int J Sports Med. 2000 Jan;21(1):21-4. doi: 10.1055/s-2000-8852.
An intense physical exercise induces an inflammatory reaction as demonstrated by the delayed increase in blood of acute phase proteins and among them of C-reactive protein (CRP). There is also evidence for a diminished acute phase reaction due to regular exercise suggesting a suppression of the inflammatory response through training. With this background CRP was measured by a sensitive enzyme immunoassay under resting conditions before and after 9 months of training in 14 subjects preparing for a marathon with the aim of studying the effect of training on the base-line CRP concentration. The mean distance run per week increased significantly from 31 +/- 9 km at the beginning to 53 +/- 15 km after 8 months of training (p < 0.01). The aerobic capacity rose significantly after training as demonstrated by the increase of running velocity during a maximal treadmill test from 3.82 +/- 0.29 m/s pre-training to 4.17 +/- 0.17 m/s post-training at a blood lactate concentration of 4 mmol/L (p < 0.01). In 10 of 12 runners base-line CRP was diminished after training in spite of a continuous increase of training intensity. The CRP median fell from 1.19 mg/L before to 0.82 mg/L after training (p < 0.05). Since intense physical exercise is known to be associated with an inflammatory reaction of muscles and tendons, the CRP decrease was unexpected. In 2 subjects the CRP concentration rose markedly because of a borrelia infection and a knee injury, respectively. These values were caused by a pathological condition and were not considered for the statistical evaluation. In 10 non-training control subjects the CRP median did not change significantly during the same 9 months period. The decrease of the CRP base-line concentration after training suggests that intensive regular exercise has a systemic anti-inflammatory effect. This is of particular interest with regard to several recent reports confering on the concentration of CRP in plasma a predictive value for the risk of cardiac infarction, venous thrombosis or stroke.
高强度体育锻炼会引发炎症反应，急性期蛋白血液水平延迟升高以及其中C反应蛋白（CRP）升高即证明了这一点。也有证据表明，经常锻炼会使急性期反应减弱，这表明通过训练可抑制炎症反应。在此背景下，对14名准备参加马拉松的受试者在训练9个月前后的静息状态下，通过灵敏的酶免疫测定法测量CRP，目的是研究训练对基线CRP浓度的影响。每周平均跑步距离从开始时的31±9公里显著增加到训练8个月后的53±15公里（p<0.01）。训练后有氧能力显著提高，在最大跑步机测试中，血乳酸浓度为4 mmol/L时，跑步速度从训练前的3.82±0.29米/秒增加到训练后的4.17±0.17米/秒即证明了这一点（p<0.01）。在12名跑步者中的10名中，尽管训练强度持续增加，但训练后基线CRP仍降低。CRP中位数从训练前的1.19毫克/升降至训练后的0.82毫克/升（p<0.05）。由于已知高强度体育锻炼与肌肉和肌腱的炎症反应有关，因此CRP降低出乎意料。在2名受试者中，CRP浓度分别因伯氏疏螺旋体感染和膝盖受伤而显著升高。这些值是由病理状况引起的，未纳入统计评估。在10名非训练对照受试者中，CRP中位数在相同的9个月期间没有显著变化。训练后CRP基线浓度降低表明，高强度定期锻炼具有全身抗炎作用。鉴于最近几份报告赋予血浆中CRP浓度对心肌梗死、静脉血栓形成或中风风险的预测价值，这一点尤其令人关注。
