Hoffmann O, Weih M, Schreiber S, Einhäupl K M, Valdueza J M
Department of Neurology, University Hospital Charité, Humboldt University Berlin, Germany.
Cerebrovasc Dis. 2000 Mar-Apr;10(2):142-6. doi: 10.1159/000016043.
We present a new, non-invasive ultrasound method for the measurement of cerebral circulation time. After injection of a galactose-based echo-contrast agent (Levovist) into an antecubital vein, cerebral circulation time is measured as the interval between the beginning of a stable signal enhancement of at least 5 dB in the internal carotid artery and in the ipsilateral internal jugular vein. Both vessels are insonated simultaneously at the mandibular angle using a single 2-MHz range-gated transducer. For this study, 25 healthy volunteers ranging in age from 23 to 55 years (30.1 +/- 7.5 years; mean +/- SD) were examined. Cerebral circulation time was 5.6 +/- 1.7 s without significant side-to-side or sex-related differences. Measurement of circulation times offers a new possibility for the employment of echo-contrast agents in functional ultrasound.
我们提出了一种用于测量脑循环时间的新型非侵入性超声方法。将基于半乳糖的超声造影剂（Levovist）注入肘前静脉后，脑循环时间被测量为颈内动脉和同侧颈内静脉中至少5 dB稳定信号增强开始之间的间隔。使用单个2-MHz距离选通换能器在下颌角同时对两根血管进行超声检查。在本研究中，对25名年龄在23至55岁之间（30.1 +/- 7.5岁；平均值 +/- 标准差）的健康志愿者进行了检查。脑循环时间为5.6 +/- 1.7秒，无明显的左右差异或性别相关差异。循环时间的测量为在功能性超声中使用超声造影剂提供了新的可能性。
