He Jiabei, Zhu Ling, Zhu Huichen, Gu Xinyu, Li Peiying, Yang Yuting, Yang Liqun
Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
BMC Anesthesiol. 2018 Apr 10;18(1):38. doi: 10.1186/s12871-018-0502-z.
Opioid-induced cough (OIC) is one of the most common complications of opioids during anesthesia induction. This study was designed to assess the incidence of OIC mediated by different intravenous route.
A total of 102(ASA I-II) scheduled for elective surgery under general anesthesia were randomly allocated into two groups: central vein group (group CV, n = 51) and peripheral vein group (group PV, n = 51). The incidence, onset time and severity of OIC were evaluated within 1 min just after sufentanil injection during induction. Meanwhile, heart rate (HR) and blood pressure (BP) were also recorded to assess the hemodynamic changes.
The incidence of OIC was 10/51 (20.4%) in group CV and 16/51 (32%) in group PV, patients received central venous administration of sufentanil experienced less OIC compared with those injected by peripheral venous route (P < 0.05), as well as a significantly lower incidence of severe OIC (P < 0.05). Nevertheless, the onset of OIC and hemodynamic data were comparable between two groups (P > 0.05).
Our study indicates that sufentanil administration by central venous route reduces the incidence and severity of OIC, but without significant changes in hemodynamic status.
Chinese Clinical Trial Registry with registration number ChiCTR-IOR-15006075 . Registered 28 February 2015.
阿片类药物诱发的咳嗽（OIC）是麻醉诱导期间阿片类药物最常见的并发症之一。本研究旨在评估不同静脉途径介导的OIC发生率。
总共102例（ASA I-II级）计划在全身麻醉下进行择期手术的患者被随机分为两组：中心静脉组（CV组，n = 51）和外周静脉组（PV组，n = 51）。在诱导期间注射舒芬太尼后1分钟内评估OIC的发生率、发作时间和严重程度。同时，还记录心率（HR）和血压（BP）以评估血流动力学变化。
CV组OIC发生率为10/51（20.4%），PV组为16/51（32%），与外周静脉途径注射舒芬太尼的患者相比，接受中心静脉注射舒芬太尼的患者发生OIC的情况较少（P < 0.05），严重OIC的发生率也显著较低（P < 0.05）。然而，两组之间OIC的发作和血流动力学数据具有可比性（P > 0.05）。
我们的研究表明，通过中心静脉途径给予舒芬太尼可降低OIC的发生率和严重程度，但血流动力学状态无显著变化。
中国临床试验注册中心，注册号ChiCTR-IOR-15006075。2015年2月28日注册。
