Lin S, Jiang S, Wu X, Qian Y, Wang D, Tang G, Gu N
Shanghai Mental Health Center, Shanghai, People's Republic of China.
Am J Med Genet. 2000 Feb 7;96(1):12-4. doi: 10.1002/(sici)1096-8628(20000207)96:1<12::aid-ajmg4>3.0.co;2-s.
To ascertain whether mood disorders, including bipolar and unipolar, are genetically associated with the monoamine oxidase A (MAOA) or monoamine oxidase B (MAOB) gene in the Chinese population, 132 cases of mood disorder and 88 normal controls were genotyped for the MAOA(CA)n, MAOB(GT)n, and MAOB(TG)n loci by the method of amplification fragment length polymorphism. Among 132 cases with mood disorder, eight alleles (size: 112-126 bp) of locus MAOA(CA)n, 12 alleles (size: 168-198 bp) of locus MAOB(GT)n, and nine alleles (size: 195-213 bp) of locus MAOB(TG)n were observed. Comparison of the allele frequency of the three loci showed no difference between mood disorder cases and normal controls on average. When each group was stratified into several subgroups, significant differences were found. On the MAOA(CA)n locus, the frequency of 116 bp allele was higher in the female bipolar disorder cases (0.2581) compared with that in the female unipolar disorder patients (0.1154) (Z=2.15, p<0. 05). On the MAOB(GT)n locus, the frequency of 180 bp allele was higher in bipolar disorder patients (0.1579) than that in normal controls (0.0678) (Z=2.05, p<0.05). The frequency of this allele was even higher in female bipolar disorder patients (0.1719) than that in female normal controls (0.0541). On the MAOB(TG)n locus, the frequency of 205 bp allele was higher in female bipolar disorder patients (0.6406) than that in female normal controls (0.4375) (Z=2. 17, p<0.05). For the unipolar disorder patients, the frequency of this allele was higher in female cases (0.5222) than that in male cases (0.1818) (Z=3.49, p<0.05). As for association studies, significant association between bipolar disorder and MAOB gene was detected. For the 180 bp allele of MAOB(GT)n, the relative risk (RR) of biploar versus normal control was 2.58 (p<0.05), and the RR of female bipolar disorder versus female normal control was 3.63 (p<0. 05). For the 205 bp allele of MAOB(TG)n, the RR of female bipolar disorder versus female normal control was 2.29 (p<0.05). Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:12-14, 2000.
为确定包括双相情感障碍和单相情感障碍在内的心境障碍在中国人群中是否与单胺氧化酶A（MAOA）或单胺氧化酶B（MAOB）基因存在遗传关联，采用扩增片段长度多态性方法对132例心境障碍患者和88例正常对照进行MAOA(CA)n、MAOB(GT)n和MAOB(TG)n位点的基因分型。在132例心境障碍患者中，观察到MAOA(CA)n位点的8个等位基因（大小：112 - 126 bp）、MAOB(GT)n位点的12个等位基因（大小：168 - 198 bp）以及MAOB(TG)n位点的9个等位基因（大小：195 - 213 bp）。对这三个位点的等位基因频率进行比较，总体上心境障碍患者与正常对照之间无差异。当将每组进一步分层为几个亚组时，发现了显著差异。在MAOA(CA)n位点，女性双相情感障碍患者中116 bp等位基因的频率（0.2581）高于女性单相情感障碍患者（0.1154）（Z = 2.15，p < 0.05）。在MAOB(GT)n位点，双相情感障碍患者中180 bp等位基因的频率（0.1579）高于正常对照（0.0678）（Z = 2.05，p < 0.05）。该等位基因在女性双相情感障碍患者中的频率（0.1719）甚至高于女性正常对照（0.0541）。在MAOB(TG)n位点，女性双相情感障碍患者中205 bp等位基因的频率（0.6406）高于女性正常对照（0.4375）（Z = 2.17，p < 0.05）。对于单相情感障碍患者，该等位基因在女性患者中的频率（0.5222）高于男性患者（0.1818）（Z = 3.49，p < 0.05）。至于关联研究，检测到双相情感障碍与MAOB基因之间存在显著关联。对于MAOB(GT)n的180 bp等位基因，双相情感障碍相对于正常对照的相对风险（RR）为2.58（p < 0.05），女性双相情感障碍相对于女性正常对照的RR为3.63（p < 0.05）。对于MAOB(TG)n的205 bp等位基因，女性双相情感障碍相对于女性正常对照的RR为2.29（p < 0.05）。《美国医学遗传学杂志（神经精神遗传学）》96:12 - 14，2000年。
