SLC6A4、PAH、GABRB3和MAOB基因多态性与精神障碍特征的改变
Polymorphisms in SLC6A4, PAH, GABRB3, and MAOB and modification of psychotic disorder features.
作者信息
Bergen Sarah E, Fanous Ayman H, Walsh Dermot, O'Neill F Anthony, Kendler Kenneth S
机构信息
Virginia Commonwealth University, Department of Human and Molecular Genetics, Richmond, Virginia 23219, USA.
出版信息
Schizophr Res. 2009 Apr;109(1-3):94-7. doi: 10.1016/j.schres.2009.02.009. Epub 2009 Mar 5.
We tested four genes [phenylalanine hydroxylase (PAH), the serotonin transporter (SLC6A4), monoamine oxidase B (MAOB), and the gamma-aminobutyric acid A receptor beta-3 subunit (GABRB3)] for their impact on five schizophrenia symptom factors: delusions, hallucinations, mania, depression, and negative symptoms. In a 90 family subset of the Irish Study of High Density Schizophrenia Families, the PAH 232 bp microsatellite allele demonstrated significant association with the delusions factor using both QTDT (F=8.0, p=.031) and QPDTPHASE (chi-square=12.54, p=.028). Also, a significant association between the GABRB3 191 bp allele and the hallucinations factor was detected using QPDTPHASE (chi-square=15.51, p=.030), but not QTDT (chi-square=2.07, p=.560).
我们测试了四个基因[苯丙氨酸羟化酶（PAH）、血清素转运体（SLC6A4）、单胺氧化酶B（MAOB）和γ-氨基丁酸A受体β-3亚基（GABRB3）]对五种精神分裂症症状因子的影响：妄想、幻觉、躁狂、抑郁和阴性症状。在爱尔兰高密度精神分裂症家族研究的90个家族子集中，使用QTDT（F = 8.0，p = 0.031）和QPDTPHASE（卡方= 12.54，p = 0.028）方法，PAH 232 bp微卫星等位基因与妄想因子显示出显著关联。此外，使用QPDTPHASE（卡方= 15.51，p = 0.030）检测到GABRB3 191 bp等位基因与幻觉因子之间存在显著关联，但使用QTDT未检测到（卡方= 2.07，p = 0.560）。
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