Ustündağ B, Canatan H, Cinkilinç N, Halifeoğlu I, Bahçecioğlu I H
Department of Biochemistry, College of Medicine, Firat (Euphrates) University, Elaziğ, Turkey.
Cell Biochem Funct. 2000 Mar;18(1):23-8. doi: 10.1002/(SICI)1099-0844(200001/03)18:1<23::AID-CBF843>3.0.CO;2-0.
Involvement of complications is considered to be one of the major factors in the prognosis of diabetes mellitus (DM). Recent studies indicate that most diabetic complications such as nephropathy and hypertension are vascular-originated. Renin-angiotensin involvement, especially changes in ACE activity level, is considered to be a key factor since ACE converts angiotensin I to angiotensin II which is a potent vasoconstrictor and plays a vital role in the regulation of blood pressure. Our present study focused on ACE activity levels along with blood glucose and HbA(1c) levels in diabetic patients with (n=18) or without (n=25) nephropathy as compared to control subjects (n=25). Blood glucose levels were significantly higher in both diabetic groups compared to controls (p<0.001). On the other hand, compared to controls, blood HbA(1c) levels were slightly higher in DM patients without complications whereas they were significantly increased in nephropatic DM patients (p<0.001). There was a very strong increase (p<0.001) at the level of ACE activity in both of the diabetic groups (with nephropathy: 47.11+/-3.70 U l(-1); without complications: 43.72+/-2.93 U l(-1); controls: 25.15+/-2.30 U l(-1)). ACE activity levels were also significantly higher in diabetic patients with nephropathy than in type II DM patients without complication (p<0.01). Our results demonstrate that ACE activity levels are increased in diabetic patients. Additional significant increase in ACE activity levels in diabetic patients with complications such as nephropathy supports the hypothesis that ACE activity has an essential role in the development of complications in diabetes.
并发症的出现被认为是糖尿病（DM）预后的主要因素之一。最近的研究表明，大多数糖尿病并发症，如肾病和高血压，都起源于血管。肾素 - 血管紧张素的参与，特别是ACE活性水平的变化，被认为是一个关键因素，因为ACE将血管紧张素I转化为血管紧张素II，血管紧张素II是一种强效血管收缩剂，在血压调节中起着至关重要的作用。我们目前的研究重点是患有（n = 18）或未患有（n = 25）肾病的糖尿病患者与对照组（n = 25）相比的ACE活性水平以及血糖和糖化血红蛋白（HbA1c）水平。与对照组相比，两个糖尿病组的血糖水平均显著更高（p<0.001）。另一方面，与对照组相比，无并发症的糖尿病患者的血液糖化血红蛋白（HbA1c）水平略高，而肾病糖尿病患者的该水平则显著升高（p<0.001）。两个糖尿病组的ACE活性水平均有非常显著的升高（p<0.001）（患有肾病：47.11±3.70 U l-1；无并发症：43.72±2.93 U l-1；对照组：25.15±2.30 U l-1）。患有肾病的糖尿病患者的ACE活性水平也显著高于无并发症的II型糖尿病患者（p<0.01）。我们的结果表明，糖尿病患者的ACE活性水平升高。患有肾病等并发症的糖尿病患者的ACE活性水平进一步显著升高，支持了ACE活性在糖尿病并发症发展中起重要作用的假说。
