Nikzamir Abdolrahim, Nakhjavani Manouchehr, Esteghamati Alireza, Rashidi Armin
Endocrinology and Metabolism Research Center, Vali-Asr Hospital, Medical Sciences/University of Tehran, Iran.
Nephrol Dial Transplant. 2008 Apr;23(4):1274-7. doi: 10.1093/ndt/gfm745. Epub 2007 Nov 6.
The activity of the renin-angiotensin-aldosterone system (RAAS) plays an important role in the development and progression of diabetic nephropathy. However, the effect of angiotensin-converting enzyme (ACE) inhibition on the RAAS appears to be modulated by a number of factors including the I/D polymorphism of the ACE genotype. In this study, we attempted to find independent correlates of ACE activity in 121 macroalbuminuric type 2 diabetic Iranian patients under chronic ACE inhibition. Both univariate and multivariate analyses were used. The presence of the D allele was independently associated with significantly higher levels of ACE activity (with the II genotype as reference, P < 0.001, B = 27.3, 95% CI = 17.6-37.1), and this association was not eliminated by potentially confounding variables. In conclusion, the D allele is a significant independent correlate of ACE activity in macroalbuminuric type 2 diabetic Iranian patients under long-term ACE inhibition.
肾素-血管紧张素-醛固酮系统（RAAS）的活性在糖尿病肾病的发生和发展中起重要作用。然而，血管紧张素转换酶（ACE）抑制对RAAS的作用似乎受到多种因素的调节，包括ACE基因的I/D多态性。在本研究中，我们试图在121例接受慢性ACE抑制治疗的伊朗2型糖尿病大量白蛋白尿患者中寻找ACE活性的独立相关因素。采用了单变量和多变量分析。D等位基因的存在与ACE活性显著升高独立相关（以II基因型为参照，P<0.001，B=27.3，95%可信区间=17.6-37.1），且这种关联未被潜在的混杂变量消除。总之，在长期接受ACE抑制治疗的伊朗2型糖尿病大量白蛋白尿患者中，D等位基因是ACE活性的一个重要独立相关因素。
