Ostrander E A, Galibert F, Patterson D F
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N., D4-100, Seattle, WA 98109-1024, USA.
Trends Genet. 2000 Mar;16(3):117-24. doi: 10.1016/s0168-9525(99)01958-7.
The dog, as human's favored companion, is unique among animal species in providing new insights into human genetic disease. In this review, we will discuss both the breed and the population structure of dogs and why that makes canines amenable to genetic studies. We will review the current state of the map and discuss the particular disease states in which canines stand to make the greatest contribution to medical genetics.
狗作为人类喜爱的伴侣，在动物物种中独一无二，能为人类遗传疾病提供新的见解。在这篇综述中，我们将讨论狗的品种和种群结构，以及为何它们适合进行遗传学研究。我们将回顾图谱的现状，并讨论狗在哪些特定疾病状态下对医学遗传学能做出最大贡献。
