Department of Ethology, ELTE Eötvös Loránd University, Budapest, Hungary.
MTA-ELTE Comparative Ethology Research Group, Budapest, Hungary.
Geroscience. 2021 Aug;43(4):1653-1668. doi: 10.1007/s11357-021-00373-7. Epub 2021 May 10.
Biobanking refers to the systematic collection, storage, and distribution of pre- or post-mortem biological samples derived from volunteer donors. The demand for high-quality human specimens is clearly demonstrated by the number of newly emerging biobanking facilities and large international collaborative networks. Several animal species are relevant today in medical research; therefore, similar initiatives in comparative physiology could be fruitful. Dogs, in particular, are gaining increasing attention in translational research on complex phenomena, like aging, cancer, and neurodegenerative diseases. Therefore, biobanks gathering and storing dog biological materials together with related data could play a vital role in translational and veterinary research projects. To achieve these aims, a canine biobank should meet the same standards in sample quality and data management as human biobanks and should rely on well-designed collaborative networks between different professionals and dog owners. While efforts to create dog biobanks could face similar financial and technical challenges as their human counterparts, they can widen the spectrum of successful collaborative initiatives towards a better picture of dogs' physiology, disease, evolution, and translational potential. In this review, we provide an overview about the current state of dog biobanking and introduce the "Canine Brain and Tissue Bank" (CBTB)-a new, large-scale collaborative endeavor in the field.
生物库是指系统地收集、存储和分发来自志愿者供体的生前或死后的生物样本。新出现的生物库设施和大型国际合作网络的数量清楚地表明了对高质量人类标本的需求。在医学研究中，有几个动物物种是相关的；因此，在比较生理学方面类似的举措可能会有成效。在复杂现象（如衰老、癌症和神经退行性疾病）的转化研究中，狗尤其受到关注。因此，汇集和储存狗的生物材料并结合相关数据的生物库可以在转化和兽医研究项目中发挥重要作用。为了实现这些目标，犬生物库应在样本质量和数据管理方面达到与人类生物库相同的标准，并依赖于不同专业人员和犬主之间精心设计的合作网络。虽然创建犬生物库可能会面临与人类生物库类似的财务和技术挑战，但它们可以拓宽成功合作举措的范围，更好地了解狗的生理学、疾病、进化和转化潜力。在这篇综述中，我们概述了犬生物库的现状，并介绍了“犬脑和组织库”（CBTB）——这是该领域的一项新的大规模合作努力。
