Majós Carles, Aguilera Carles, Cos Mònica, Camins Angels, Candiota Ana P, Delgado-Goñi Teresa, Samitier Alex, Castañer Sara, Sánchez Juan J, Mato David, Acebes Juan J, Arús Carles
Institut de Diagnòstic per la Imatge, Centre Bellvitge, Hospital Universitari de Bellvitge, Autovia de Castelldefels km 2.7, 08907, L'Hospitalet de Llobregat, Barcelona, Spain.
Eur Radiol. 2009 Aug;19(8):2049-59. doi: 10.1007/s00330-009-1357-y. Epub 2009 Mar 11.
The aim of this study was to assess the usefulness of proton MR spectroscopy in the diagnosis of intraventricular tumours. Fifty-two intraventricular tumours pertaining to 16 different tumour types were derived from our database. All cases had single-voxel proton MR spectroscopy performed at TE at both 30 and 136 ms at 1.5 T. The Mann-Whitney U test was used to search for the most discriminative datapoints each tumour type. Characteristic trends were found for some groups: high Glx and Ala in meningiomas (p < 0.001 and p < 0.01, respectively), high mobile lipids in metastasis (p < 0.001), high Cho in PNET (p < 0.001), high mI + Gly in ependymoma (p < 0.001), high NAC (p < 0.01) in the absence of the normal brain parenchyma pattern in colloid cysts, and high mI/Gly and Ala in central neurocytoma. Proton MR spectroscopy provides additional metabolic information that could be useful in the diagnosis of intraventricular brain tumors.
本研究的目的是评估质子磁共振波谱在诊断脑室内肿瘤中的作用。从我们的数据库中选取了52例属于16种不同肿瘤类型的脑室内肿瘤。所有病例均在1.5T场强下，于30ms和136ms的回波时间（TE）进行了单体素质子磁共振波谱检查。采用曼-惠特尼U检验来寻找每种肿瘤类型最具鉴别力的数据点。在一些组中发现了特征性趋势：脑膜瘤中谷氨酰胺+谷氨酸（Glx）和丙氨酸（Ala）含量高（分别为p < 0.001和p < 0.01），转移瘤中可移动脂质含量高（p < 0.001），原始神经外胚层肿瘤（PNET）中胆碱（Cho）含量高（p < 0.001），室管膜瘤中肌醇（mI）+甘氨酸含量高（p < 0.001），胶体囊肿在无正常脑实质模式时N-乙酰天门冬氨酸（NAC）含量高（p < 0.01），中枢神经细胞瘤中mI/甘氨酸和丙氨酸含量高。质子磁共振波谱提供了额外的代谢信息，这可能有助于脑室内脑肿瘤的诊断。
