Nikas G
Department of Obstetrics and Gynaecology, Imperial College School of Science, Technology and Medicine, Hammersmith Hospital, London, UK.
Hum Reprod. 1999 Dec;14 Suppl 2:99-106. doi: 10.1093/humrep/14.suppl_2.99.
Clinical evidence indicates the existence in the human of a narrow window of uterine receptivity which opens during the mid-luteal phase. At the same time, formation of pinopodes on the apical membranes of the endometrial epithelial cells occurs. To develop a specific marker for receptivity in clinical practice, the kinetics of pinopode formation has been investigated through sequential endometrial biopsying in natural, hormone replacement and stimulated cycles. The results show that pinopodes last <48 h in all cycles, and the timing of their formation depends both on the hormonal treatment applied and on the patient's individual response. On average, pinopodes form earlier in stimulated cycles and later in hormone replacement cycles, compared with natural cycles. Pinopode expression is strongly correlated with implantation following embryo transfer and furthermore, detection of pinopodes in assessment cycles may be extremely useful for the assessment of receptivity on an individual basis to optimize embryo transfer, resulting in increased implantation rates. Finally, pinopodes seem to be correlated well with other cellular and molecular events occurring in the mid-luteal endometrium.
临床证据表明，人类存在一个狭窄的子宫容受期窗口，该窗口在黄体中期开启。与此同时，子宫内膜上皮细胞顶端膜上会形成微绒毛。为了在临床实践中开发一种容受性的特异性标志物，通过在自然周期、激素替代周期和促排卵周期中进行连续的子宫内膜活检，对微绒毛形成的动力学进行了研究。结果表明，在所有周期中微绒毛持续时间均小于48小时，其形成时间既取决于所应用的激素治疗，也取决于患者的个体反应。平均而言，与自然周期相比，微绒毛在促排卵周期中形成较早，而在激素替代周期中形成较晚。微绒毛的表达与胚胎移植后的着床密切相关，此外，在评估周期中检测微绒毛对于个体化评估容受性以优化胚胎移植可能极为有用，从而提高着床率。最后，微绒毛似乎与黄体中期子宫内膜中发生的其他细胞和分子事件密切相关。
