Iester M, Mermoud A, Schnyder C
Hopital Ophtalmique Jules Gonin, Lausanne, Switzerland.
Ophthalmology. 2000 Feb;107(2):288-94. doi: 10.1016/s0161-6420(99)00058-5.
To ascertain whether frequency doubling technique (FDT) (Welch-Allyn, Skaneateles, NY; Zeiss-Humphrey, San Leandro, CA) indices provide results comparable with those of standard Octopus threshold perimeters (Interzeag AG, CH-8952 Schlieren, CH) in patients with glaucoma and in patients suspected of having ocular hypertension, glaucoma, or both.
A comparative, consecutive, case series.
Thirty-nine glaucomatous patients and 41 patients with ocular hypertension or suspected glaucoma were recruited consecutively.
The visual field of the study participants were assessed by FDT program C-20 full threshold and Octopus program dG1X. Only one eye of each participant was selected randomly. Pearson's r correlation coefficient was calculated among the FDT and Octopus indices.
Using Octopus perimeter, mean defect (MD), mean sensitivity (MS), loss variance (LV), and corrected loss variance (CLV) were calculated and used for correlation. For the FDT, mean deviation (FDT-MD) and pattern standard deviation (FDT-PSD) were calculated and used for correlation. Also, the time required to perform the visual field test was considered.
In the entire population, a statistically significant correlation (Pearson's r, P<0.001) was found between FDT-MD and both MS (0.77) and MD (-0.80) and between FDT-PSD and both LV (0.50) and CLV (0.45). When the glaucoma group was considered alone, similar significant correlation was found between the indices. In the suspected ocular hypertension and glaucoma suspect group, no significant correlation was found. A significant (P<0.001) difference was found between FDT and Octopus for the time needed to perform the visual field test.
This new technique could be used both to screen populations and to observe glaucomatous visual field progression in early and moderate stages. The FDT is a faster way to analyze the visual field and captures threshold values for each point, but it is important to remember that this is a new technique and its limits are still unknown.
确定倍频技术（FDT）（美国纽约州斯卡奈特勒斯的Welch-Allyn公司；美国加利福尼亚州圣莱安德罗的蔡司-汉弗莱公司）指标在青光眼患者以及疑似患有高眼压症、青光眼或两者皆有的患者中所提供的结果是否与标准的Octopus阈值视野计（瑞士施利伦Interzeag AG公司，邮编CH-8952）的结果相当。
一项比较性、连续性病例系列研究。
连续招募了39例青光眼患者以及41例高眼压症患者或疑似青光眼患者。
通过FDT程序C-20全阈值和Octopus程序dG1X评估研究参与者的视野。每个参与者仅随机选择一只眼睛。计算FDT和Octopus指标之间的Pearson相关系数r。
使用Octopus视野计计算平均缺损（MD）、平均敏感度（MS）、损失方差（LV）和校正损失方差（CLV）并用于相关性分析。对于FDT，计算平均偏差（FDT-MD）和模式标准差（FDT-PSD）并用于相关性分析。此外，还考虑了进行视野测试所需的时间。
在整个人群中，FDT-MD与MS（0.77）和MD（-0.80）之间以及FDT-PSD与LV（0.50）和CLV（0.45）之间均存在统计学显著相关性（Pearson相关系数r，P<0.001）。单独考虑青光眼组时，各指标之间也存在类似的显著相关性。在疑似高眼压症和青光眼可疑组中，未发现显著相关性。FDT和Octopus在进行视野测试所需时间方面存在显著（P<0.001）差异。
这项新技术可用于人群筛查以及观察青光眼早期和中期的视野进展情况。FDT是一种更快的视野分析方法，可获取每个点的阈值，但重要的是要记住这是一项新技术，其局限性仍然未知。
