酵母糖酵解振荡中细胞内和细胞间动力学的转导
Transduction of intracellular and intercellular dynamics in yeast glycolytic oscillations.
作者信息
Wolf J, Passarge J, Somsen O J, Snoep J L, Heinrich R, Westerhoff H V
机构信息
Humboldt University, Institute of Biology, Theoretical Biophysics, Invalidenstrasse 42, D-10115 Berlin, Germany.
出版信息
Biophys J. 2000 Mar;78(3):1145-53. doi: 10.1016/S0006-3495(00)76672-0.
Abstract
Under certain well-defined conditions, a population of yeast cells exhibits glycolytic oscillations that synchronize through intercellular acetaldehyde. This implies that the dynamic phenomenon of the oscillation propagates within and between cells. We here develop a method to establish by which route dynamics propagate through a biological reaction network. Application of the method to yeast demonstrates how the oscillations and the synchronization signal can be transduced. That transduction is not so much through the backbone of glycolysis, as via the Gibbs energy and redox coenzyme couples (ATP/ADP, and NADH/NAD), and via both intra- and intercellular acetaldehyde.
摘要
在某些明确界定的条件下，一群酵母细胞会表现出通过细胞间乙醛实现同步的糖酵解振荡。这意味着振荡这一动态现象在细胞内和细胞间传播。我们在此开发了一种方法来确定动力学通过生物反应网络传播的途径。将该方法应用于酵母，展示了振荡和同步信号是如何被转导的。这种转导并非主要通过糖酵解的主干途径，而是通过吉布斯自由能和氧化还原辅酶对（ATP/ADP和NADH/NAD），以及通过细胞内和细胞间的乙醛来实现的。
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