Itoh Z, Nakaya M, Suzuki T, Arai H, Wakabayashi K
Am J Physiol. 1984 Dec;247(6 Pt 1):G688-94. doi: 10.1152/ajpgi.1984.247.6.G688.
The gastrointestinal motor stimulating activity of erythromycin (EM) was studied in conscious dogs. It was found that a 20-min intravenous infusion of EM lactobionate at a dose of 50-100 micrograms (potency) X kg-1 X h-1 induced a group of strong contractions in the stomach and the duodenum, and the contractions migrated along the small intestine to the terminal ileum. The EM-induced contractions were quite similar to the naturally occurring interdigestive migrating contractions (IMC) in the gastrointestinal tract in frequency, contractile force, and duration of the contractions, migrating velocity, and accompanying peaks of plasma motilin concentration. The EM-induced contractions in the stomach were inhibited by feeding and intravenous infusion of pentagastrin (1.5 micrograms X kg-1 X h-1) but were not affected by secretin; these findings are identical to those found with the naturally occurring and motilin-induced contractions. Like motilin, EM stimulated motor activity only during the interdigestive state. We conclude that EM induces IMC associated with the release of endogenous motilin in the dog.
在清醒犬中研究了红霉素（EM）的胃肠运动刺激活性。发现以50 - 100微克（效价）×千克⁻¹×小时⁻¹的剂量静脉输注乳糖酸红霉素20分钟，可在胃和十二指肠诱发一组强烈收缩，且收缩沿小肠向回肠末端迁移。EM诱发的收缩在频率、收缩力、收缩持续时间、迁移速度以及伴随的血浆胃动素浓度峰值方面，与胃肠道自然发生的消化间期移行性收缩（IMC）非常相似。进食和静脉输注五肽胃泌素（1.5微克×千克⁻¹×小时⁻¹）可抑制EM诱发的胃收缩，但不受促胰液素影响；这些发现与自然发生的和胃动素诱发的收缩情况相同。与胃动素一样，EM仅在消化间期刺激运动活性。我们得出结论，EM在犬中诱发与内源性胃动素释放相关的IMC。
