轻度髋臼发育不良与老年白人女性发生髋骨关节炎风险增加的关联：骨质疏松性骨折研究
Association of mild acetabular dysplasia with an increased risk of incident hip osteoarthritis in elderly white women: the study of osteoporotic fractures.
作者信息
Lane N E, Lin P, Christiansen L, Gore L R, Williams E N, Hochberg M C, Nevitt M C
机构信息
Division of Rheumatology, University of California at San Francisco, 94143, USA.
出版信息
Arthritis Rheum. 2000 Feb;43(2):400-4. doi: 10.1002/1529-0131(200002)43:2<400::AID-ANR21>3.0.CO;2-D.
OBJECTIVE
To determine if acetabular dysplasia increases the risk of incident hip osteoarthritis (OA) among elderly white women.
METHODS
Baseline and followup anteroposterior pelvic radiographs were obtained a mean of 8 years apart, and read for individual radiographic features (IRFs) of hip OA; summary grades (0-4) were then assigned based on the IRFs present. Acetabular dysplasia was defined by the results of measurements of the acetabular depth (<9 mm) or the center-edge angle (<30 degrees). Logistic regression analyses were performed to determine the association between acetabular dysplasia and incident hip OA, and all analyses were adjusted for age, current weight, body mass index, affected side, and investigational site.
RESULTS
The odds ratios for the association of abnormal center-edge angle and acetabular dysplasia with incident hip OA were 3.3 (95% confidence interval 1.1-10.1) and 2.8 (95% confidence interval 1.0-7.9), respectively.
CONCLUSION
Acetabular dysplasia, defined by a decrease in the center-edge angle, is associated with a modestly increased risk of incident hip OA in elderly white women.
目的
确定髋臼发育不良是否会增加老年白人女性发生髋骨关节炎（OA）的风险。
方法
平均间隔8年获取基线和随访时的骨盆前后位X线片，并对髋骨关节炎的个体放射学特征（IRF）进行解读；然后根据存在的IRF指定总结分级（0 - 4级）。髋臼发育不良由髋臼深度测量结果（<9毫米）或中心边缘角测量结果（<30度）定义。进行逻辑回归分析以确定髋臼发育不良与新发髋骨关节炎之间的关联，所有分析均针对年龄、当前体重、体重指数、患侧和研究地点进行了调整。
结果
中心边缘角异常和髋臼发育不良与新发髋骨关节炎关联的优势比分别为3.3（95%置信区间1.1 - 10.1）和2.8（95%置信区间1.0 - 7.9）。
结论
以中心边缘角减小定义的髋臼发育不良与老年白人女性新发髋骨关节炎风险适度增加相关。
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