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黏液成分对结肠腺癌生存的影响:一项多因素分析。

Influence of mucinous components on survival in colorectal adenocarcinomas: a multivariate analysis.

作者信息

Halvorsen T B, Seim E

机构信息

Department of Pathology, Trondheim Regional and University Hospital, Norway.

出版信息

J Clin Pathol. 1988 Oct;41(10):1068-72. doi: 10.1136/jcp.41.10.1068.

DOI:10.1136/jcp.41.10.1068
PMID:2848059
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1141689/
Abstract

Of 534 resected colorectal adenocarcinomas, 165 (31%) contained some mucinous components; these represented the main part of the tumour in 67 (13%). Of the mucin containing tumours, 63 (38%) were in the right colon compared with 50 (13%) of the non-mucinous ones (p less than 0.001). Patients with predominantly mucinous tumours were significantly older than those with non-mucinous tumours, and they tended to present with tumours at a more advanced stage. A multivariate analysis did not show any significant independent prognostic influence of the mucinous component except when this had a predominantly signet ring cell pattern.

摘要

在534例切除的结肠直肠腺癌中,165例(31%)含有一些黏液成分;其中67例(13%)黏液成分是肿瘤的主要部分。在含黏液的肿瘤中,63例(38%)位于右半结肠,而非黏液性肿瘤中这一比例为50例(13%)(P<0.001)。以黏液性肿瘤为主的患者比非黏液性肿瘤患者年龄显著更大,且他们的肿瘤往往处于更晚期阶段。多因素分析未显示黏液成分有任何显著的独立预后影响,但当黏液成分主要为印戒细胞模式时除外。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f966/1141689/1845781c4b2d/jclinpath00342-0037-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f966/1141689/1845781c4b2d/jclinpath00342-0037-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f966/1141689/1845781c4b2d/jclinpath00342-0037-a.jpg

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本文引用的文献

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THE GRADING AND PROGNOSIS OF CARCINOMA OF THE COLON AND RECTUM.结肠癌和直肠癌的分级与预后
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The prognostic significance of specific histologic features of carcinoma of the colon and rectum.结肠直肠癌特定组织学特征的预后意义。
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BMC Cancer. 2024 Sep 19;24(1):1161. doi: 10.1186/s12885-024-12905-3.
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Mucinous histology is a negative predictor of neoadjuvant chemoradiotherapy for locally advanced rectal adenocarcinoma.黏液组织学是局部晚期直肠腺癌新辅助放化疗的阴性预测因子。
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Mucinous and Non-Mucinous Rectal Adenocarcinoma-Differences in Treatment Response to Preoperative Radiotherapy.黏液性和非黏液性直肠腺癌——术前放疗治疗反应的差异
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Adenocarcinoma with mixed subtypes is a rare but aggressive histologic subtype in colorectal cancer.结直肠癌中混合亚型腺癌是一种罕见但侵袭性很强的组织学亚型。
BMC Cancer. 2019 Nov 8;19(1):1071. doi: 10.1186/s12885-019-6245-5.
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Cancer Med. 2019 Jul;8(7):3411-3419. doi: 10.1002/cam4.2234. Epub 2019 May 10.
10
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