Plancoulaine S, Charles M A, Lafay L, Tauber M, Thibult N, Borys J M, Eschwège E
Institut National de la Santé et de la Recherche Médicale, Unité 258, 16, avenue Paul Vaillant-Couturier, F-94807 Villejuif, France.
Eur J Clin Nutr. 2000 Feb;54(2):114-9. doi: 10.1038/sj.ejcn.1600904.
Several studies, mainly in animals, but also in humans, have shown that diet in infancy is associated with differences in blood cholesterol concentrations later in life. The objective was to examine this relationship in children aged 5-11 y after taking into account their current diet and parental hypercholesterolemia.
251 prepubertal boys and 223 prepubertal girls enrolled in the schools in two little towns in northern France.
Cross-sectional evaluation including measurements of cholesterol concentrations on capillary blood and a single weekday food intake record. Infant feeding patterns were obtained by questionnaire given to the mothers.
50% of the children had been breast-fed for a median duration of less than 2 months. Cow's milk was introduced in the diet as whole milk for 33% of the children. After adjustment for age, height, and sibship, capillary cholesterol concentration was lower in boys who had been breast fed (geometric mean: 4.4, 95% confidence interval of the mean: 4.2-4.6 mmol/L) than in those fed with formula (4.7, 4.5-4.8 mmol/L, P<0.03). In girls, breastfeeding had no significant effect on blood cholesterol concentration, which was associated with the type of cow's milk given in infancy: whole milk: 4.9 mmol/L (4.7-5. 2); totally or partially skimmed milk: 4.5 mmol/L (4.2-4.6), P<0.008. The current saturated fat and cholesterol intakes and parental hypercyholesterolemia were associated with current blood cholesterol concentration in children, but did not modify its relationship with infant feeding patterns.
Results of the present study suggest that diet in infancy may have longstanding effect on lipid metabolism.
The study was supported by funds from Eridania Béghin-Say, Groupe Fournier, Lesieur and Nestlé France, Roche Diagnostic and of the MGEN (Mutuelle Générale de l'Education Nationale, contract INSERM-MGEN #9158) and a grant from the Association de Langue Française pour l'Etude du Diabète et du Métabolisme (ALFEDIAM). European Journal of Clinical Nutrition (2000) 54, 114-119
多项研究，主要是动物研究，但也有人类研究表明，婴儿期饮食与日后生活中的血液胆固醇浓度差异有关。目的是在考虑儿童当前饮食和父母高胆固醇血症的情况下，研究5至11岁儿童中的这种关系。
法国北部两个小镇学校中的251名青春期前男孩和223名青春期前女孩。
横断面评估，包括测量毛细血管血中的胆固醇浓度和一份工作日食物摄入记录。通过向母亲发放问卷获取婴儿喂养模式。
50%的儿童母乳喂养时间中位数少于2个月。33%的儿童饮食中引入的是全脂牛奶。在对年龄、身高和同胞关系进行调整后，母乳喂养的男孩毛细血管胆固醇浓度（几何均值：4.4，均值的95%置信区间：4.2 - 4.6 mmol/L）低于配方奶喂养的男孩（4.7，4.5 - 4.8 mmol/L，P<0.03）。在女孩中，母乳喂养对血液胆固醇浓度无显著影响，血液胆固醇浓度与婴儿期所喂牛奶的类型有关：全脂牛奶：4.9 mmol/L（4.7 - 5.2）；全脱脂或部分脱脂牛奶：4.5 mmol/L（4.2 - 4.6），P<0.008。儿童当前的饱和脂肪和胆固醇摄入量以及父母高胆固醇血症与儿童当前的血液胆固醇浓度有关，但并未改变其与婴儿喂养模式的关系。
本研究结果表明婴儿期饮食可能对脂质代谢有长期影响。
本研究由埃里达尼亚·贝金 - 赛伊公司、富尔尼集团、莱斯厄尔公司和雀巢法国公司、罗氏诊断公司以及MGEN（国家教育互助总会，合同编号INSERM - MGEN #9158）提供资金支持，以及法国糖尿病与代谢研究法语协会（ALFEDIAM）的一项资助。《欧洲临床营养学杂志》（2000年）54卷第114 - 119页
