Victora Cesar G, Horta Bernardo L, Post Paulo, Lima Rosângela C, De Leon Elizalde Jacqueline W, Gerson Branca Maria Cerezer, Barros Fernando C
Post-Graduate Programme in Epidemiology, Universidade Federal de Pelotas, CP 464, 96001-970 Pelotas, RS, Brazil.
J Epidemiol Community Health. 2006 Jul;60(7):621-5. doi: 10.1136/jech.2005.044156.
To assess the association between breast feeding and blood lipid levels in adolescence.
Population based prospective birth cohort study.
City of Pelotas, Brazil.
All hospital births taking place in 1982; 79% of all males (n = 2250) were followed up for 18 years, and 2089 blood samples were available.
None.
Total cholesterol and fractions (very low density lipoprotein cholesterol (VLDL), low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL)), LDL/HDL ratio, serum triglycerides.
Three breast feeding variables were studied: total duration of breast feeding, duration of exclusive or predominant breast feeding, and ever compared with never breast fed. Adjusted analyses were controlled for family income, household assets index, maternal education, maternal pre-pregnancy body mass index (BMI), skin colour, birth weight, gestational age, maternal smoking during pregnancy, and adolescent BMI, and behavioural variables (fat content of diet, physical activity, smoking, and alcohol drinking). Only one association reached borderline significance (p = 0.05): LDL cholesterol was slightly higher among never (mean 41.0 mg/dl; 95% CI 39.4 to 42.7) than among ever breast fed men (38.6 mg/dl; 95% CI 38.6 to 40.3), in the adjusted analyses. All other associations were not significant (p> or =0.09). There was no evidence of effect modification according to preterm status, intrauterine growth retardation, socioeconomic level, growth velocity in the first two years of life, or nutritional status at 2 years of age.
There was no clear association between breast feeding duration and serum lipid concentrations at the age of 18 years in this sample of Brazilian men.
评估母乳喂养与青少年血脂水平之间的关联。
基于人群的前瞻性出生队列研究。
巴西佩洛塔斯市。
1982年在该市医院出生的所有婴儿；对所有男性中的79%（n = 2250）进行了18年的随访，共获得2089份血样。
无。
总胆固醇及其组分（极低密度脂蛋白胆固醇（VLDL）、低密度脂蛋白胆固醇（LDL）、高密度脂蛋白胆固醇（HDL））、LDL/HDL比值、血清甘油三酯。
研究了三个母乳喂养变量：母乳喂养总时长、纯母乳喂养或主要母乳喂养时长，以及曾经母乳喂养与从未母乳喂养的比较。校正分析控制了家庭收入、家庭资产指数、母亲教育程度、母亲孕前体重指数（BMI）、肤色、出生体重、孕周、孕期母亲吸烟情况以及青少年BMI，还有行为变量（饮食脂肪含量、身体活动、吸烟和饮酒）。在校正分析中，只有一种关联达到临界显著水平（p = 0.05）：从未母乳喂养的男性中LDL胆固醇略高于曾经母乳喂养的男性（分别为均值41.0mg/dl；95%可信区间39.4至42.7，以及38.6mg/dl；95%可信区间38.6至40.3）。所有其他关联均不显著（p≥0.09）。未发现根据早产状态、宫内生长迟缓、社会经济水平、生命最初两年的生长速度或2岁时的营养状况进行效应修正的证据。
在这个巴西男性样本中，母乳喂养时长与18岁时的血清脂质浓度之间没有明确关联。
