van de Vijver L P, Kardinaal A F, Couet C, Aro A, Kafatos A, Steingrimsdottir L, Amorim Cruz J A, Moreiras O, Becker W, van Amelsvoort J M, Vidal-Jessel S, Salminen I, Moschandreas J, Sigfússon N, Martins I, Carbajal A, Ytterfors A, Poppel G
Department of Consumer Research and Epidemiology, TNO Nutrition and Food Research Institute, Zeist, The Netherlands.
Eur J Clin Nutr. 2000 Feb;54(2):126-35. doi: 10.1038/sj.ejcn.1600906.
High intakes of trans fatty acids (TFA) have been found to exert an undesirable effect on serum lipid profiles, and thus may increase the risk for cardiovascular disease.
Investigation of the association between TFA intake and serum lipids.
Cross-sectional study in eight European countries (Finland, France, Greece, Iceland, The Netherlands, Portugal, Spain, Sweden) among 327 men and 299 women (50-65 y). Using a dietary history method, food consumption was assessed and TFA intake was calculated with recent figures on TFA levels of foods, collected in the TRANSFAIR study.
Mean (+/-s.d.) TFA intake was 2.40+/-1.53 g/day for men and 1.98+/-1.49 g/day for women (0.87+/-0.48% and 0. 95+/-0.55% of energy, respectively), with the highest consumption in Iceland and the lowest in the Mediterranean countries. No associations were found between total TFA intake and LDL, HDL or LDL/HDL ratio after adjustment for cardiovascular risk factors. Additional adjustment for other fatty acid clusters resulted in a significant inverse trend between total TFA intake and total cholesterol (Ptrend<0.03). The most abundantly occurring TFA isomer, C18:1 t, contributed substantially to this inverse association. The TFA isomers C14:1 t9, C16:1 t9 and C22:1 t were not associated or were positively associated with LDL or total cholesterol.
From this study we conclude that at the current European intake levels of trans fatty acids they are not associated with an unfavourable serum lipid profile.
Unilever Research Laboratorium, the Dutch Dairy Foundation on Nutrition and Health, Cargill BV, the Institute of Food Research Norwich Laboratory, the Nutrition Branch of the Ministry of Agriculture, Fisheries and Food, the International Fishmeal and Oil Manufacturers' Association, Kraft Foods, NV Vandemoortele Coordination Center, Danone Group, McDonalds Deutschland Inc, Danish Veterinary and Food Administration, Valio Ltd, Raisio Group. European Journal of Clinical Nutrition (2000) 54, 126-135
已发现高摄入反式脂肪酸（TFA）会对血清脂质谱产生不良影响，因此可能增加心血管疾病风险。
研究TFA摄入量与血清脂质之间的关联。
对八个欧洲国家（芬兰、法国、希腊、冰岛、荷兰、葡萄牙、西班牙、瑞典）的327名男性和299名女性（50 - 65岁）进行横断面研究。采用饮食史方法评估食物摄入量，并根据TRANSFAIR研究中收集的食物TFA水平最新数据计算TFA摄入量。
男性的平均（±标准差）TFA摄入量为2.40±1.53克/天，女性为1.98±1.49克/天（分别占能量的0.87±0.48%和0.95±0.55%），冰岛的摄入量最高，地中海国家最低。在对心血管危险因素进行调整后，未发现总TFA摄入量与低密度脂蛋白（LDL）、高密度脂蛋白（HDL）或LDL/HDL比值之间存在关联。对其他脂肪酸组进行进一步调整后，总TFA摄入量与总胆固醇之间呈现显著的负向趋势（Ptrend<0.03）。最常见的TFA异构体C18:1 t对这种负向关联有很大贡献。TFA异构体C14:1 t9、C16:1 t9和C22:1 t与LDL或总胆固醇无关联或呈正相关。
从本研究我们得出结论，在欧洲目前的反式脂肪酸摄入水平下，它们与不良的血清脂质谱无关。
联合利华研究实验室、荷兰营养与健康乳制品基金会、嘉吉公司、食品研究所诺维奇实验室、农业、渔业和食品部营养司、国际鱼粉和鱼油制造商协会、卡夫食品公司、NV Vandemoortele协调中心、达能集团、麦当劳德国公司、丹麦兽医和食品管理局、瓦利奥有限公司、拉西奥集团。《欧洲临床营养学杂志》（2000年）54卷，126 - 135页
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