McNiven M A, Cao H, Pitts K R, Yoon Y
Dept of Biochemistry and Molecular Biology, The Center for Basic Research in Digestive Diseases, Mayo Foundation, Rochester, MN 55905, USA.
Trends Biochem Sci. 2000 Mar;25(3):115-20. doi: 10.1016/s0968-0004(99)01538-8.
The large GTPase dynamin is a mechanoenzyme that mediates the liberation of nascent clathrin-coated pits from the plasma membrane during endocytosis. Recently, this enzyme has been demonstrated to comprise an extensive family of related proteins that have been implicated in a large variety of vesicle trafficking events during endocytosis, secretion and even maintenance of mitochondrial form. The potential contributions by the dynamin family to these diverse but related functions are discussed.
大型GTP酶发动蛋白是一种机械酶，在胞吞作用过程中介导新生网格蛋白包被小窝从质膜上释放。最近，已证明这种酶包含一个广泛的相关蛋白家族，这些蛋白与胞吞作用、分泌甚至线粒体形态维持过程中的多种囊泡运输事件有关。本文讨论了发动蛋白家族对这些不同但相关功能的潜在贡献。
