从负鼠（Didelphis marsupialis）血清中分离出的抗矛头蝮蛇毒组分对矛头蝮蛇毒的痛觉过敏活性的抑制作用。

Inhibition of the hyperalgesic activity of Bothrops jararaca venom by an antibothropic fraction isolated from opossum (Didelphis marsupialis) serum.

作者信息

Rocha S L, Frutuoso V S, Domont G B, Martins M A, Moussatché H, Perales J

机构信息

Departamento de Fisiologia e Farmacodinâmica, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brazil.

出版信息

Toxicon. 2000 Jun;38(6):875-80. doi: 10.1016/s0041-0101(99)00190-7.

DOI:10.1016/s0041-0101(99)00190-7

PMID:10695972

Abstract

The antibothropic fraction (ABF) already isolated from Didelphis marsupialis serum, inhibits the haemorrhagic, oedematogenic, myonecrotic and lethal activities of Bothrops jararaca venom (Bjv). The aim of this work was to verify the capability of ABF to inhibit the hyperalgesic activity of Bjv. Intraplantar injection of Bjv induced hyperalgesia in a time- and dose-dependent manner and ABF administered in situ concomitantly with Bjv or i.v. 30 min before venom injection reduced the induced hyperalgesia. This same effect was observed when ABF was intravenously injected at 5 and 15 min after Bjv. Our results show that ABF inhibits also the hyperalgesia induced by Bjv.

摘要

已从负鼠血清中分离出的抗蝰蛇毒组分（ABF），可抑制巴西矛头蝮蛇毒（Bjv）的出血、致水肿、肌坏死和致死活性。本研究的目的是验证ABF抑制Bjv痛觉过敏活性的能力。足底注射Bjv可诱导痛觉过敏，且呈时间和剂量依赖性，与Bjv同时原位给药或在毒液注射前30分钟静脉注射ABF可减轻诱导的痛觉过敏。当在Bjv注射后5分钟和15分钟静脉注射ABF时，也观察到了相同的效果。我们的结果表明，ABF也可抑制Bjv诱导的痛觉过敏。