Daurio C P, Holste J E, Andrews F M, Merritt A M, Blackford J T, Dolz F, Thompson D R
Merial Limited, Iselin, New Jersey 08830-3077, USA.
Equine Vet J Suppl. 1999 Apr(29):59-62. doi: 10.1111/j.2042-3306.1999.tb05171.x.
In a multicentre trial, 13 cannulated horses were treated orally once daily with a paste that delivered omeprazole at a dose of 4 and 5 mg/kg bwt in a 2-period crossover design to evaluate steady state gastric acid suppression. In each period, basal (unstimulated) and pentagastrin-stimulated gastric output were evaluated at 5-8 h after 5 doses, at 13-16 h after 10 doses, and at 21-24 h after 15 doses. Baseline data for gastric acid secretion were collected once for each horse in the month prior to initiation of omeprazole treatment. The inhibition of gastric acid secretion relative to baseline values, following treatment with omeprazole, were calculated and expressed as per cent. Pharmacokinetic data were also collected in this trial. At 4 mg/kg bwt, the oral paste formulation of omeprazole inhibited both basal and pentagastrin-stimulated gastric acid secretion by 99% at 5-8 h after treatment and by 83% (basal) and 90% (pentagastrin-stimulated) at 21-24 h. Inhibition following the administration of omeprazole at a dose of 5 mg/kg bwt was not significantly greater than when given at 4 mg/kg bwt. The results from this study could possibly lead to the development of an effective and practical antisecretory treatment of ulcer disease in horses.
在一项多中心试验中，13匹插有胃管的马采用两阶段交叉设计，每天口服一次含有奥美拉唑的糊剂，剂量分别为4毫克/千克体重和5毫克/千克体重，以评估稳态胃酸抑制情况。在每个阶段，分别在5剂后5 - 8小时、10剂后13 - 16小时以及15剂后21 - 24小时评估基础（未刺激）胃酸分泌和五肽胃泌素刺激后的胃酸分泌。在开始奥美拉唑治疗前一个月，每匹马收集一次胃酸分泌的基线数据。计算奥美拉唑治疗后相对于基线值的胃酸分泌抑制率，并以百分比表示。该试验还收集了药代动力学数据。在4毫克/千克体重剂量下，奥美拉唑口服糊剂在治疗后5 - 8小时对基础胃酸分泌和五肽胃泌素刺激后的胃酸分泌均抑制99%，在21 - 24小时分别抑制83%（基础）和90%（五肽胃泌素刺激）。5毫克/千克体重剂量的奥美拉唑给药后的抑制作用并不显著大于4毫克/千克体重剂量时。本研究结果可能会促成一种有效且实用的马匹溃疡病抗分泌治疗方法的开发。
