Vatistas N J, Snyder J R, Nieto J, Thompson D, Pollmeier M, Holste J
Department of Veterinary Surgical and Radiological Sciences, University of California, Davis 95616, USA.
Equine Vet J Suppl. 1999 Apr(29):71-6. doi: 10.1111/j.2042-3306.1999.tb05174.x.
Gastric ulceration has been found to occur in 80-90% of Thoroughbreds in active race training. Previously, variable success has been reported using mucosal surface protectants and H2 receptor antagonist. Omeprazole, a substituted benzimidazole, has been shown to inhibit gastric acid secretion in both man and animals. Fourteen horses, in active race training and with endoscopic evidence of moderated to severe gastric ulceration were divided into 2 groups: Group 1 (7 horses) were given placebo paste orally once daily for 28 days; Group 2 (7 horses) received 1.54 g active omeprazole in the placebo once daily for 28 days. Logs detailing administration and acceptability of the paste, and the horse's feeding and training regime were maintained by the trainer of each horse. Endoscopic examination of the stomach occurred at the beginning of the trial, and at 13-17 days and 27-31 days following commencement of the trial. Those horses that were free of ulceration on Days 27-31 were reexamined on Days 35-49. Acceptability of the paste, whether with or without active omeprazole, was deemed excellent in all horses except on one occasion, when one horse swallowed the paste following initial mild reluctance. Of the horses given the placebo (Group 1), 3 were withdrawn after the 13-17 day endoscopic examination: 1 horse to be given a H2 receptor antagonist, 1 horse was removed from training due to aryepiglottic entrapment and 1 horse had a greater than 10% fall in bodyweight from the start of the trial. Of the horses given active omeprazole (Group 2), one horses was relocated to another race track following the 13-17 day endoscopic examination. For the horses given placebo (Group 1), there was no change in the severity of ulceration. In contrast, the severity of ulceration in the horses given active omeprazole was significantly reduced at 13-17 days and 27-31 days. In 2 Group 2 horses, ulcers that had been completely eliminated subsequently returned when reexamined at 35-49 days. The results of this study suggest that omeprazole, employing a once daily dosing schedule, is effective at reducing the severity or eliminating gastric ulcers in Thoroughbreds in active race training.
据发现，在积极进行赛马训练的纯种马中，80%-90%会出现胃溃疡。此前，使用粘膜表面保护剂和H2受体拮抗剂的效果不一。奥美拉唑是一种取代苯并咪唑，已被证明在人和动物中均能抑制胃酸分泌。14匹正在积极进行赛马训练且经内窥镜检查有中度至重度胃溃疡的马被分为两组：第1组（7匹马）每天口服一次安慰剂糊剂，持续28天；第2组（7匹马）每天在安慰剂中服用1.54克活性奥美拉唑，持续28天。每匹马的训练师记录了糊剂给药和可接受性的详细情况，以及马的进食和训练情况。在试验开始时、试验开始后13-17天和27-31天对马进行胃部内窥镜检查。在第27-31天没有溃疡的马在第35-49天重新检查。除了有一次一匹马最初稍有不情愿后吞下了糊剂外，无论糊剂中是否含有活性奥美拉唑，所有马对糊剂的接受性都被认为很好。在接受安慰剂的马（第1组）中，3匹马在第13-17天内窥镜检查后退出：1匹马将接受H2受体拮抗剂治疗，1匹马因杓会厌襞陷入而停止训练，1匹马自试验开始体重下降超过10%。在接受活性奥美拉唑的马（第2组）中，1匹马在第13-17天内窥镜检查后被转移到另一个赛马场。对于接受安慰剂的马（第1组），溃疡严重程度没有变化。相比之下，接受活性奥美拉唑的马在第13-17天和27-31天溃疡严重程度显著降低。在第2组的2匹马中，完全消除的溃疡在第35-49天重新检查时又复发了。这项研究的结果表明，采用每日一次给药方案的奥美拉唑对降低积极进行赛马训练的纯种马胃溃疡的严重程度或消除胃溃疡是有效的。
