Matsuo T, Itami M, Shiraga F
Department of Ophthalmology, Okayama University Medical School, Okayama City, Japan.
Retina. 2000;20(1):16-21. doi: 10.1097/00006982-200001000-00003.
To examine choroidopathy in patients with sarcoidosis.
In a prospective clinical study, 10 consecutive patients (20 eyes) with sarcoidosis underwent simultaneous indocyanine green (ICG) and fluorescein angiography (FA) with a double detector of scanning laser ophthalmoscopy. Angiographic findings recorded on videotapes were evaluated, and the relation of ICG angiographic findings with systemic activity and the extent of retinal inflammation was analyzed.
Indocyanine green angiographic findings, not evident with fluorescein, were multiple lobular hypofluorescent spots in the posterior pole in 10 eyes of 5 patients, isolated hypofluorescent plaques in 2 eyes of 1 patient, hyperfluorescent spots in 3 eyes of 2 patients, and segmental choroidal vascular wall staining in 6 eyes of 4 patients. The multiple lobular hypofluorescent spots with ICG were observed at a significantly higher rate in eyes with extensive retinal vascular leakage of fluorescein than in eyes with minimal leakage (chi-square test, P = 0.0007).
The patients with sarcoidosis showed choroidal abnormalities that could be revealed by ICG angiography, but not by funduscopy or FA. Simultaneous ICG and FA angiography may be useful for examining choroidal lesions in sarcoidosis.
研究结节病患者的脉络膜病变。
在一项前瞻性临床研究中，10例连续的结节病患者（20只眼）使用扫描激光眼底镜双探测器同时进行吲哚菁绿（ICG）和荧光素血管造影（FA）。对录像带上记录的血管造影结果进行评估，并分析ICG血管造影结果与全身活动及视网膜炎症程度的关系。
ICG血管造影发现而荧光素检查未发现的表现为：5例患者的10只眼中后极部有多个小叶状低荧光斑，1例患者的2只眼中有孤立的低荧光斑块，2例患者的3只眼中有高荧光斑，4例患者的6只眼中有节段性脉络膜血管壁染色。ICG显示的多个小叶状低荧光斑在荧光素血管渗漏广泛的眼中出现的比例显著高于渗漏轻微的眼（卡方检验，P = 0.0007）。
结节病患者表现出脉络膜异常，ICG血管造影可显示这些异常，而眼底检查或FA则不能。同时进行ICG和FA血管造影可能有助于检查结节病的脉络膜病变。
