Matsuo T, Sato Y, Shiraga F, Shiragami C, Tsuchida Y
Department of Ophthalmology, Okayama University Medical School, Japan.
Ophthalmology. 1999 Feb;106(2):295-300. doi: 10.1016/S0161-6420(99)90069-6.
To examine choroidopathy in patients with Behçet disease.
Prospective clinical study.
Thirty-three patients (63 eyes) with Behçet disease.
Patients underwent simultaneous indocyanine green (ICG) and fluorescein angiography with a double detector of scanning laser ophthalmoscopy.
Angiographic findings recorded on videotapes were evaluated. The relation of angiographic findings with systemic activity and aqueous inflammation was also analyzed.
Fluorescein angiography showed leakage in varying degrees from retinal vessels in 30 patients (53 eyes, 84%). The ICG angiographic findings were choroidal vascular wall staining in 16 eyes (25%), hyperfluorescent spots in 42 eyes (66%) and hypofluorescent plaques in 22 eyes (35%), both of which were not evident with fluorescein, leakage from choroidal vessels in 3 eyes (5%), and irregular filling of choriocapillaris in 11 eyes (17%). These findings did not have a statistically significant correlation with the presence or absence of aqueous inflammation or oral aphthous ulcerations.
The patients with Behçet disease showed choroidal abnormalities, which could be revealed only by ICG angiography, but not with funduscopy or fluorescein angiography. Simultaneous ICG and fluorescein angiography would be useful for examining choroidal lesions in Behçet disease.
研究白塞病患者的脉络膜病变。
前瞻性临床研究。
33例白塞病患者（63只眼）。
患者使用扫描激光眼底镜双探测器同时进行吲哚菁绿（ICG）和荧光素血管造影。
评估录像记录的血管造影结果。分析血管造影结果与全身活动及房水炎症的关系。
荧光素血管造影显示30例患者（53只眼，84%）的视网膜血管有不同程度渗漏。ICG血管造影结果为16只眼（25%）脉络膜血管壁染色、42只眼（66%）高荧光斑点和22只眼（35%）低荧光斑块，荧光素造影均未显示这些情况，3只眼（5%）脉络膜血管渗漏，11只眼（17%）脉络膜毛细血管充盈不规则。这些结果与房水炎症或口腔溃疡的有无无统计学显著相关性。
白塞病患者存在脉络膜异常，仅ICG血管造影可显示，眼底镜检查及荧光素血管造影无法显示。ICG和荧光素联合血管造影有助于检查白塞病的脉络膜病变。
