Sharafeldin A, Eltayeb R, Pashenkov M, Bakhiet M
Division of Infectious Diseases, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden.
J Neuroimmunol. 2000 Mar 1;103(2):165-70. doi: 10.1016/s0165-5728(99)00238-6.
African trypanosomiasis is characterized by progressive central nervous system (CNS) involvement. Using single and double immunohistochemistry, we evaluated the induction of alpha- and beta-chemokines in brains of Sprague-Dawley rats infected with Trypanosoma brucei brucei (T. b. brucei) and identified their cellular source. The results showed high production of MIP-2, RANTES and MIP-1alpha and to a lower extend MCP-1 in infected animals compared to controls. MIP-2, RANTES and MIP-1alpha were produced early by astrocytes and microglia and later by macrophages and T-cells. These findings suggest that chemokines may contribute to the immunopathogenesis that occurs in the CNS early during infections.
非洲锥虫病的特征是中枢神经系统（CNS）进行性受累。我们采用单重和双重免疫组化方法，评估了感染布氏布氏锥虫（T. b. brucei）的Sprague-Dawley大鼠脑中α-和β-趋化因子的诱导情况，并确定了它们的细胞来源。结果显示，与对照组相比，感染动物中MIP-2、RANTES和MIP-1α的产生量较高，而MCP-1的产生量较低。MIP-2、RANTES和MIP-1α早期由星形胶质细胞和小胶质细胞产生，后期由巨噬细胞和T细胞产生。这些发现表明，趋化因子可能促成感染早期中枢神经系统发生的免疫病理过程。
