Bayer-Garner I B, Smoller B
Department of Pathology, The University of Arkansas for Medical Sciences, Little Rock 72205, USA.
Mod Pathol. 2000 Feb;13(2):119-22. doi: 10.1038/modpathol.3880021.
Metastatic lesions to the skin may present a dilemma in the identification of the primary site. Breast carcinoma, metastatic to the skin, that is negative for estrogen receptors (ERs) and/or progesterone receptors (PRs) may be mimicked by a number of other metastatic lesions. In the present study, 16 formalin-fixed and paraffin-embedded infiltrating ductal carcinomas metastatic to the skin, which were ER-/PR-, ER-/PR+, or ER+/PR-; 5 metastatic lesions to the skin from primary lesions other than breast cancer; and 5 eccrine tumors were examined for immunoreactivity to the androgen receptor. The majority of the metastatic breast lesions (82%) exhibited immunopositivity for androgen receptor, whereas the metastatic skin lesions from primary lesions other than breast cancer and the eccrine tumors were immunonegative. Thus, androgen receptor immunohistochemistry could serve as a marker to increase sensitivity for identifying breast cancer in skin metastasis of unknown primary sites.
皮肤转移性病变在原发部位的识别上可能会带来难题。转移至皮肤的雌激素受体（ERs）和/或孕激素受体（PRs）呈阴性的乳腺癌，可能会被许多其他转移性病变所模仿。在本研究中，对16例福尔马林固定、石蜡包埋的浸润性导管癌皮肤转移灶进行检测，这些转移灶的ER-/PR-、ER-/PR+或ER+/PR-；5例非乳腺癌原发灶的皮肤转移病变；以及5例小汗腺肿瘤进行雄激素受体免疫反应性检测。大多数转移性乳腺病变（82%）对雄激素受体呈免疫阳性，而除乳腺癌外其他原发灶的皮肤转移病变及小汗腺肿瘤则为免疫阴性。因此，雄激素受体免疫组化可作为一种标志物，提高在原发部位不明的皮肤转移癌中识别乳腺癌的敏感性。
