Triviño A, Ramírez J M, Salazar J J, Ramírez A I
Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Facultad de Medicina, Universidad Complutense Madrid, Spain.
J Anat. 2000 Jan;196 ( Pt 1)(Pt 1):61-70. doi: 10.1046/j.1469-7580.2000.19610061.x.
The immunohistochemical location of glial fibrillary acidic protein (GFAP) was used to study the state of maturation of retinal astrocytes from an 18-mo-old infant and to compare it with the situation in the adult. Infant astrocytes showed intense GFAP immunoreactivity in the perikarya and possessed spindle-like enlargements in their processes, while in the adult immunoreactivity in the perikarya was scarce and the spindle-like enlargements were not evident. Two types of astrocyte were observed in adult and child retinas: elongated and star-shaped. In the adult, the star-shaped type tend to be more stylised and to have longer processes than in the infant. In the infant, numerous astrocyte cell bodies were observed over vessels, while in the adult these were scarce. In the infant, the star-shaped astrocytes made up a honeycomb plexus, but this was not fully developed. These results suggest that at 18 mo of postnatal development the retinal astrocytes are still increasing and growing into the astroglial structure found in adults.
利用胶质纤维酸性蛋白（GFAP）的免疫组织化学定位来研究一名18个月大婴儿视网膜星形胶质细胞的成熟状态，并将其与成人的情况进行比较。婴儿星形胶质细胞在胞体中显示出强烈的GFAP免疫反应性，其突起有纺锤状膨大，而在成人中，胞体中的免疫反应性稀少，纺锤状膨大不明显。在成人和儿童视网膜中观察到两种类型的星形胶质细胞：细长型和星形。在成人中，星形类型往往比婴儿的更规整，突起更长。在婴儿中，在血管上观察到大量星形胶质细胞胞体，而在成人中则很少。在婴儿中，星形星形胶质细胞构成蜂窝状丛，但尚未完全发育。这些结果表明，在出生后18个月的发育过程中，视网膜星形胶质细胞仍在增加，并逐渐发育成成人中发现的星形胶质结构。
