Gariano R F, Kalina R E, Hendrickson A E
Department of Biological Structure, University of Washington, Seattle, USA.
Surv Ophthalmol. 1996 May-Jun;40(6):481-90. doi: 10.1016/s0039-6257(96)82014-5.
Angiogenesis is a complex biologic process that occurs normally in development and in turnover and remodeling of mature vascular networks. Pathological angiogenesis and neovascularization occur in association with retinal and ocular ischemic diseases, in retinopathy of prematurity and other developmental disorders, and in tumor growth and metastasis. We describe current understanding of cellular and molecular mechanisms of retinal vascular development, highlighting aspects that relate to eye diseases, that provide sites of therapeutic intervention in ophthalmology and that are potential avenues for research.
血管生成是一个复杂的生物学过程，正常情况下发生在发育过程以及成熟血管网络的更新和重塑过程中。病理性血管生成和新生血管形成与视网膜和眼部缺血性疾病、早产儿视网膜病变及其他发育障碍以及肿瘤生长和转移相关。我们描述了目前对视网膜血管发育的细胞和分子机制的理解，重点强调了与眼部疾病相关的方面、为眼科治疗干预提供靶点的方面以及潜在的研究途径。
