Głuszek J, Szcześniak L, Banaszak F, Tykarski A, Rychlewski T
Klinika Nadciśnienia Tetniczego i Chorób Naczyń Instytutu Kardiologii AM w Poznaniu.
Pol Arch Med Wewn. 1999 Mar;101(3):191-6.
Recently many researchers have described the presence of insulin resistance and hyperinsulinemia in a substantial number of patients with essential hypertension. Reduced insulin binding to the receptors may play important role in development of insulin resistance in these patients. The study was aimed to assess the value of insulin binding to erythrocyte receptors in the patients with essential hypertension and compare to values in healthy persons. Additional purpose was the evaluation of insulin degradation by erythrocytes in patients with essential hypertension. 23 patients with essential hypertension (BMI 22.7 +/- 3.2) and 21 healthy persons (with BMI value 23.3 +/- 2.9) were studied. In all examined individuals the blood glucose and blood insulin concentrations were determined, insulin binding to erythrocyte receptors and insulin degradation by erythrocytes were measured by the method of Gambhir and al. Insulin concentration was significantly higher in patients with essential hypertension than in healthy subjects. We demonstrated a statistically significant positive correlation between body weight and insulin concentration in blood serum only in healthy people. Insulin binding to the receptors of red blood cells was significantly stronger (p < 0.001) in healthy persons than in patients with essential hypertension (0.972 +/- 0.395 pg 10(11) RBC and 0.446 +/- 0.14 pg 10(11) RBC respectively). In patients with hypertension insulin binding to receptors of red blood cells does not depend on body weight and insulin concentration in blood serum. Values of insulin degradation by erythrocyte in patients with essential hypertension and healthy persons were not significantly different. It seems that decreased insulin binding to insulin receptors is an important mechanism of insulin resistance patients with essential hypertension.
最近，许多研究人员描述了大量原发性高血压患者存在胰岛素抵抗和高胰岛素血症。胰岛素与受体结合减少可能在这些患者胰岛素抵抗的发展中起重要作用。该研究旨在评估原发性高血压患者胰岛素与红细胞受体结合的价值，并与健康人的值进行比较。另一个目的是评估原发性高血压患者红细胞对胰岛素的降解情况。研究了23例原发性高血压患者（BMI 22.7±3.2）和21名健康人（BMI值23.3±2.9）。在所有受检个体中，测定了血糖和血胰岛素浓度，采用甘比尔等人的方法测量胰岛素与红细胞受体的结合以及红细胞对胰岛素的降解。原发性高血压患者的胰岛素浓度显著高于健康受试者。我们仅在健康人中发现体重与血清胰岛素浓度之间存在统计学上显著的正相关。健康人红细胞受体对胰岛素的结合明显强于原发性高血压患者（分别为0.972±0.395 pg 10¹¹红细胞和0.446±0.14 pg 10¹¹红细胞，p<0.001）。在高血压患者中，红细胞对胰岛素受体的结合不依赖于体重和血清胰岛素浓度。原发性高血压患者和健康人红细胞对胰岛素的降解值无显著差异。胰岛素与胰岛素受体结合减少似乎是原发性高血压患者胰岛素抵抗的一个重要机制。
