Brinck U, Korabiowska M, Buschmann N, Stachura J, Ruschenburg I, Cordon-Cardo C, Schauer A
Department of Gastroenteropathology, Georg August University Göttingen, Germany.
Anticancer Res. 1999 Nov-Dec;19(6B):5211-6.
Ploidy associated parameters were determined in 161 malignant fibrous histiocytomas (MFH) by DNA image cytometry. The rate of euploid cases in MFH with histopathological grade I was 42%, grade II 16% and grade III 6%. Univariate analyses showed that cases with a low percentage of diploid cells (< 40%) and cases with high rates of aneuploid cells between 4c and 8c (> 9%), octaploid cells (> 0%) and 16-ploid cells (> 0%), high 2.5c (> 60%) and 5c (> 16%) exceeding rates and cases with high DNA indices of the first (> 1.08) and the second (> 3.78) peak had significantly reduced survival rates. Multivariate analyses with Cox regression demonstrated that in addition to grade, only the percentage of aneuploid cells between 4c and 8c, the 5c exceeding rate and the DNA index of the first peak had independent prognostic impact. It was concluded that besides ploidy status and grading, ploidy associated parameters are suited for prediction of survival in MFH.
通过DNA图像细胞术对161例恶性纤维组织细胞瘤（MFH）的倍性相关参数进行了测定。组织病理学I级的MFH中整倍体病例的比例为42%，II级为16%，III级为6%。单因素分析显示，二倍体细胞比例低（<40%）以及4c至8c之间非整倍体细胞比例高（>9%）、八倍体细胞（>0%）和16倍体细胞（>0%）、2.5c（>60%）和5c（>16%）的超标率高以及第一个峰（>1.08）和第二个峰（>3.78）的DNA指数高的病例生存率显著降低。Cox回归多因素分析表明，除分级外，只有4c至8c之间非整倍体细胞的比例、5c超标率和第一个峰的DNA指数具有独立的预后影响。得出的结论是，除了倍性状态和分级外，倍性相关参数也适用于预测MFH的生存率。
