Collins F H, Saunders R D, Kafatos F C, Roth C, Ke Z, Wang X, Dymbrowski K, Ton L, Hogan J
Department of Biological Sciences, University of Notre Dame, IN 46556, USA.
Parassitologia. 1999 Sep;41(1-3):163-8.
Within the past several years, a number of powerful genetic and genomic tools have been developed for use in research on the African malaria vector Anopheles gambiae. While these tools have been developed with a broad range of potential applications in mind, they have been particularly useful in advancing the effort to clone a set of An. gambiae genes that enable a refractory strain of this mosquito to encapsulate and kill a wide variety of different malaria parasites to which this mosquito is normally fully susceptible. This paper describes the latest progress in this map-based cloning research, which involves the collaborative contributions of a number of different laboratories in Europe and the United States.
在过去几年里，已经开发出了许多强大的遗传和基因组工具，用于对非洲疟疾媒介冈比亚按蚊的研究。虽然开发这些工具时考虑到了广泛的潜在应用，但它们在推进克隆一组冈比亚按蚊基因的工作中特别有用，这些基因能使这种蚊子的一个抗性品系包裹并杀死多种不同的疟原虫，而这种蚊子通常对这些疟原虫是完全易感的。本文描述了这项基于图谱的克隆研究的最新进展，该研究涉及欧洲和美国多个不同实验室的合作贡献。
